91120-6
Antithrombin in Platelet poor plasma by Chromo.no addition of heparin
Active
Term Description
This term represents an antithrombin (AT) assay which, in contrast to typical AT assays, is performed in the ABSENCE of heparin. This assay is also known as "Progressive antithrombin assay." It is used to identify type IIb AT deficiency, which is caused by a mutation in the AT heparin binding site (HBS). In type IIb AT deficiency, AT activity is reduced in the presence of heparin but is normal in the absence of heparin. PMID: 19141163 This term was created for, but is not limited in use to, the Biophen Antithrombin 5 assay's VARIANT Method, which is performed without heparin. In patients with type IIb AT deficiency, AT activity is expected to be normal in patients with an HBS mutation.
Source: Regenstrief LOINC
Part Descriptions
LP15394-7 Antithrombin
Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. It is a glycoprotein produced by the liver.
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Source: Wikipedia, Antithrombin (Wikipedia)
LP15394-7 Antithrombin
Antithrombin and antithrombin III refer to the same thing but today, however, antithrombin is the correct name. Antithrombin is a small glycoprotien, produced in the liver that inactivates several enzymes of the coagulation system including thrombin as well as factors Xa, IXa, XIa, XIIa, and kallikrein. Heparan sulfate (heparin), located on endothelial cells, binds to antithrombin causing a conformational change that results in its activation. Antithrombin deficiency is present in 0.17% of the general population. It accounts for 1.1% of unselected patients with venous thrombosis and up to 5% of patients younger than 70 years with thrombosis. Over 127 mutations in the antithrombin gene are known to cause hereditary antithrombin deficiency. Individuals heterozygous for antithrombin deficiency have a fivefold increased risk for venous thrombosis. Homozygous deficiencies are usually fatal.
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Fully-Specified Name
- Component
- Antithrombin
- Property
- RelCCnc
- Time
- Pt
- System
- PPP
- Scale
- Qn
- Method
- Chromo.no addition of heparin
Additional Names
- Short Name
- AT III PPP Chromo.no added heparin
- Display Name
- Antithrombin Chromo.no addition of heparin (PPP) [Rel catalytic activity/Vol]
- Consumer Name Alpha Get Info
- Antithrombin, Blood
Basic Attributes
- Class
- COAG
- Type
- Laboratory
- First Released
- Version 2.65
- Last Updated
- Version 2.65
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| de-AT | German (Austria) | Synonyms: AT III Aktivität progressiv |
| de-DE | German (Germany) | Antithrombin: Synonyms: AT |
| es-ES | Spanish (Spain) | Antitrombina: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | Antitrombina: |
| fr-FR | French (France) | Antithrombine: |
| it-IT | Italian (Italy) | Antitrombina: Synonyms: Concentrazione Catalitica Relativa Cromo senza aggiunta di eparina Cromogenico (Enzima) Plasma povero di piastrine Punto nel tempo (episodio) Studio di coagulazione |
| zh-CN | Chinese (China) | 抗凝血酶: Synonyms: Anti-Xa AT; |
Example Units
| Unit | Source |
|---|---|
| % | Example UCUM Units |
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