Log In

Term Description

This term represents an antithrombin (AT) assay which, in contrast to typical AT assays, is performed in the ABSENCE of heparin. This assay is also known as "Progressive antithrombin assay." It is used to identify type IIb AT deficiency, which is caused by a mutation in the AT heparin binding site (HBS). In type IIb AT deficiency, AT activity is reduced in the presence of heparin but is normal in the absence of heparin. PMID: 19141163 This term was created for, but is not limited in use to, the Biophen Antithrombin 5 assay's VARIANT Method, which is performed without heparin. In patients with type IIb AT deficiency, AT activity is expected to be normal in patients with an HBS mutation.

Part Descriptions

LP15394-7   Antithrombin
Antithrombin is a small molecule that inactivates several enzymes of the coagulation system. It is a glycoprotein produced by the liver. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Antithrombin (Wikipedia)

LP15394-7   Antithrombin
Antithrombin and antithrombin III refer to the same thing but today, however, antithrombin is the correct name. Antithrombin is a small glycoprotien, produced in the liver that inactivates several enzymes of the coagulation system including thrombin as well as factors Xa, IXa, XIa, XIIa, and kallikrein. Heparan sulfate (heparin), located on endothelial cells, binds to antithrombin causing a conformational change that results in its activation. Antithrombin deficiency is present in 0.17% of the general population. It accounts for 1.1% of unselected patients with venous thrombosis and up to 5% of patients younger than 70 years with thrombosis. Over 127 mutations in the antithrombin gene are known to cause hereditary antithrombin deficiency. Individuals heterozygous for antithrombin deficiency have a fivefold increased risk for venous thrombosis. Homozygous deficiencies are usually fatal. Source: Regenstrief Help

LOINC Names Get Info

Fully-Specified Name
Antithrombin:RelCCnc:Pt:PPP:Qn:Chromo.no addition of heparin
Long Common Name
Antithrombin in Platelet poor plasma by Chromo.no addition of heparin
Short Name
AT III PPP Chromo.no added heparin
Display Name
Antithrombin Chromo.no addition of heparin (PPP) [Rel catalytic activity/Vol]
Consumer Name Alpha Get Info
Antithrombin, Blood

Part Model Get Info

  • Component
    Antithrombin
    LP15394-7
    • Analyte
      Antithrombin
      LP15394-7
      • Component Numerator
        Antithrombin
        LP15394-7
        • Component Numerator Core
          Antithrombin
          LP15394-7
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    RelCCnc
    LP31739-3
  • Time
    Pt
    LP6960-1
  • System
    PPP
    LP7494-0
    • System Core
      PPP
      LP7494-0
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    Chromo.no addition of heparin
    LP270158-1

Basic Attributes

Class
COAG
Type
Laboratory
First Released
Version 2.65
Last Updated
Version 2.65 (ADD)
Order vs. Observation
Observation

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Antitrombin:Relativní katalytická koncentrace:Časový bod:Plazma chudá na trombocyty:Kvantitativní:Chromogenní metoda.bez přídavku heparinu
de-ATGerman (Austria)Synonyms: AT III Aktivität progressiv
de-DEGerman (Germany)Antithrombin:Relative katalytische Konzentration:Zeitpunkt:Thrombozytenarmes Plasma:Quantitativ:Chromogene Methode.ohne Heparinzusatz
Synonyms: AT
el-GRGreek (Greece)Αντιθρομβίνη:RelCCnc:Pt:PPP:Qn:Χρωμο.χωρίς προσθήκη ηπαρίνης
Synonyms: Chromo COAG PPP Pt Qn RelCCnc Αντιθρομβίνη Χρωμο.χωρίς προσθήκη ηπαρίνης
es-ESSpanish (Spain)Antitrombina:Concentración catalítica relativa:Punto temporal:Plasma pobre en plaquetas:Qn:método cromogénico sin adición de heparina
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Antitrombina:Concentración catalítica relativa:Punto temporal:Plasma pobre en plaquetas:Cuantitativo:Cromo sin adición de heparina
fr-FRFrench (France)Antithrombine:Activité catalytique relative:Ponctuel:Plasma pauvre en plaquettes:Numérique:Technique chromogénique sans héparine
it-ITItalian (Italy)Antitrombina:RelCCnc:Pt:PPP:Qn:Cromo.senza aggiunta di eparina
Synonyms: Concentrazione Catalitica Relativa Cromo senza aggiunta di eparina Cromogenico (Enzima) Plasma povero di piastrine Punto nel tempo (episodio) Studio di coagulazione
pl-PLPolish (Poland)Antytrombina:względne stężenie katalityczne:punkt w czasie:osocze ubogopłytkowe:ilościowy:metoda z substratem chromogennym bez dodatku heparyny
Synonyms: AT PPP
zh-CNChinese (China)抗凝血酶:相对催化浓度:时间点:贫血小板血浆:定量型:凝血因子酶学测定法.不添加肝素
Synonyms: Anti-Xa AT;AT III;凝血酶抑制剂 I;抗凝血酶 III;抗凝血酶Ⅲ;抗凝血酶-III;抗硫胺素;抗硫胺素 III;抗硫胺素Ⅲ;肝素辅因子 I;肝素辅酶 I 乏血小板血浆;Platelet poor plasma;PPP 凝血功能;凝血功能试验;凝血过程;血液凝固;血液凝固功能;血液凝固过程 凝血因子发色测定方法.不添加肝素（肝磷脂、肝制凝素）;凝血因子发色测定法.不添加肝素;凝血因子酶学测定方法.不添加肝素;发色法.不添加肝素;发色测定方法.不添加肝素;发色测定法.不添加肝素;显色法.不添加肝素;显色测定方法.不添加肝素;显色测定法.不添加肝素;酶学法.不添加肝素;酶学测定方法.不添加肝素;酶学测定法.不添加肝素;酶法.不添加肝素 凝血因子发色测定方法;凝血因子发色测定法;凝血因子酶学测定方法;发色法;发色测定方法;发色测定法;显色法;显色测定方法;显色测定法;酶学法;酶学测定方法;酶学测定法;酶法 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 抗Xa 抗Xa活性 抗因子Xa 抗因子Xa活性 时刻;随机;随意;瞬间 肝素 发色 肝素 发色法 肝素 发色测定方法 肝素 发色测定法 肝素 显色法 肝素 显色测定方法 肝素 显色测定法 肝素 酶学法 肝素 酶学测定方法 肝素 酶学测定法 肝素 酶法

Example Units

UnitSource
%Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=91120-6