LOINC
Version 2.73

91543-9Myelin oligodendrocyte glycoprotein Ab [Presence] in Cerebral spinal fluid by Cell binding immunofluorescent assayActive

Part Descriptions

LP231891-5   Myelin oligodendrocyte glycoprotein Ab
Myelin oligodendrocyte glycoprotein (MOG) is a protein made up of two polypeptides with molecular masses of 26 and 28 kilodaltons, respectively. MOG is located on the surface of myelin and oligodendrocyte cytoplasmic membranes and binds to the monoclonal antibody 8-18C5. [PMID:1373175] MOG is a probable autoantigen target associated with multiple sclerosis (MS) and other demyelinating diseases (DD) of the central nervous system. [PMID:1373175] That being said, there is variation in the level of MOG antibody found in patients with MS and DD with inconsistencies between MOG antibody measurements using western blot and ELISA test methods, making it a questionable biomarker for DD. [PMID:17294606] MOG IgG1 is the most prevalent isotype of IgG in patients with DD.[PMID:29063242] Source: Regenstrief LOINC

LP269367-1   CBA IFA
In cell binding assays or cell-based assays (CBA) also known as cell-based immunoassays, the DNA coding for a particular antigen is transfected into cultured cells, which are then used directly as substrate for antibody detection by immunofluorescence. The advantage of CBA IFA over conventional immunoassays is that purification and stability of the antigen is not required and they provide an in vivo substrate. Source: Regenstrief LOINC

Fully-Specified Name

Component
Myelin oligodendrocyte glycoprotein Ab
Property
PrThr
Time
Pt
System
CSF
Scale
Ord
Method
CBA IFA

Additional Names

Short Name
MOG Ab CSF Ql CBA IFA
Display Name
Myelin oligodendrocyte glycoprotein Ab Cell binding immunofluorescent assay Ql (CSF)
Consumer Name Alpha
Myelin oligodendrocyte glycoprotein antibody, Spinal fluid

Example Answer List LL360-9

Source: Regenstrief Institute

Answer Code Score Answer ID
Positive Copyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
Negative Copyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.69
Order vs. Observation
Both

Language Variants Get Info

zh-CNChinese (China)
髓鞘少突胶质细胞糖蛋白 抗体:存在情况或阈值:时间点:脑脊液:序数型:CBA IFA
fr-FRFrench (France)
MOG anticorps:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunofluorescence CBA
it-ITItalian (Italy)
Glicoproteina oligodendrocita mielinica Ab:PrThr:Pt:LCS:Ord:CBA IFA
es-MXSpanish (Mexico)
Glicoproteína de oligodendrocitos de mielina Ab:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Ensayo inmunofluorescente de unión a células
es-ESSpanish (Spain)
Mielina de oligodendrocitos glicoproteína Anticuerpos:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:CBA IFA (inmunofluorescencia indirecta de estudio basqado en células)

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=91543-9