Rotavirus A RNA [Presence] in Stool by NAA with probe detection
LP204843-9 Rotavirus A
Rotaviruses are non-enveloped, multilayered, icosahedral viruses composed of an outer layer, an inner layer, and a core. After the immature, double-layered virus is assembled in the host cell cytoplasm, they bud across the endoplasmic reticulum (ER) and acquire a temporary membrane that has on its surface the ER resident viral glycoproteins NSP4, VP4 and VP7. The virus loses its temporary membrane and the NSP4 glycoprotein as it moves toward the center of the ER cisternae. The VP4 and VP7 proteins are pushed to the outermost membrane layer and become the mature triple-layered rotavirus. The outer capsid glycoprotein VP7 is believed to be important for the attachment to and entry in the host cell. After it enters the host cell, the VP7 glycoprotein is lost. [UniProt: Q89865] When the host cell lyses, the mature virus are released. There are eight groups of rotavirus, A through H. Groups A, B, C, and H are associated with an acute gastroenteritis and are found in humans and animals. Groups D, E, F, and G are found only in animals. Rotavirus A (RVA) are the cause an acute gastroenteritis in children and animals. RVA is the most common infectious organism to cause severe gastroenteritis in children less than 3 years of age. It is estimated that 95% of children worldwide between the ages of 3 and 5 will become infected with RVA. Approximately 8000 children under 5 years of age in Latin America and the Caribbean die of acute enteritis caused by RVA. [PMID: 2556635][http://www.sciencedirect.com/science/article/pii/S004268220700400X?via%3Dihub][PMID: 27462899] Source: Regenstrief LOINC
- Rotavirus A RNA
- Short Name
- RVA RNA Stl Ql NAA+probe
- Display Name
- Rotavirus A RNA NAA+probe Ql (Stl)
- Consumer Name Alpha
- Rotavirus A, Stool
Example Answer List: LL2038-9Source: Quest Diagnostics Inc.
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|IndeterminateCopyright http://snomed.info/sct ID:82334004 Indeterminate (qualifier value)||LA11884-6|
- First Released
- Version 2.66
- Last Updated
- Version 2.66
- Order vs. Observation
Member of these Panels
|LOINC||Long Common Name|
|79381-0||Gastrointestinal pathogens panel - Stool by NAA with probe detection|
|nl-NL||Dutch (Netherlands)||Rotavirus A RNA:
|it-IT||Italian (Italy)||Rotavirus A RNA:
|fr-FR||French (France)||Rotavirus A ARN:
|es-ES||Spanish (Spain)||Rotavirus A RNA:
|zh-CN||Chinese (China)||轮状病毒 A 组 RNA:
|de-DE||German (Germany)||Rotavirus A RNA:
|es-MX||Spanish (Mexico)||ARN del rotavirus A:
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