Version 2.78

Part Description

LP310425-6   Lyso-sphingomyelin
Lyso-sphingomyelin (LSM, sphingosylphosphorylcholine) is a biomarker for Niemann-Pick disease types A, B and C, genetically distinct metabolic disorders. Niemann-Pick types A/B and C share clinical features including hepatospenomegaly and specific neurological symptoms. Types A and B are caused by mutations in the SMPD1 gene (or acid sphingomyelinase), while type C is caused by mutations in the NPC1 or NPC2 genes. Both type A/B and C Niemann-Pick show increased plasma levels of LSM and/or its analog Lyso-sphingomyelin509 (LSM509), and it has been suggested that Niemann-Pick A and B can be biochemically distinguished from C by comparing plasma levels of LSM and LSM509. Niemann-Pick type C can also be specifically diagnosed by the levels of oxysterols in blood or plasma PMID: 28259515. Source: Regenstrief LOINC

Fully-Specified Name

Component
Lyso-sphingomyelin
Property
SCnc
Time
Pt
System
Bld.dot
Scale
Qn
Method

Additional Names

Short Name
LSM DBS-sCnc
Display Name
Lyso-sphingomyelin (DBS) [Moles/Vol]
Consumer Name Alpha Get Info
Lyso-sphingomyelin, Dried blood spot

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.66
Last Updated
Version 2.66
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
92741-8 Cholestane-3-beta, 5-alpha, 6-beta triol and Lyso-sphingomyelin panel - DBS
92745-9 Hepatosplenomegaly due to lysosomal storage disorders screening panel - DBS

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Lisoesfingomielina:Concentración de sustancia:Punto temporal:gota de sangre (papel de filtro):Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Liso-esfingomielina:Concentración de sustancias:Punto temporal:DBS:Cuantitativo:
fr-FR French (France) Lyso-sphingomyéline:Moles/Volume:Ponctuel:Sang buvard:Numérique:
it-IT Italian (Italy) Liso-sfingomielina:SCnc:Pt:Sangue.su carta da filtro:Qn:
Synonyms: Chimica Concentrazione di Sostanza Punto nel tempo (episodio) Sangue Spot sangue secco
zh-CN Chinese (China) 溶血鞘磷脂:物质的量浓度:时间点:全血.斑点:定量型:
Synonyms: 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 全血斑点(滤纸);滤纸;血液.斑点;血液斑点(滤纸) 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 神经磷脂;神经鞘骨磷脂;鞘磷脂 神经鞘氨醇磷酸胆碱;Sphingosylphosphorylcholine;CAS 82970-80-7 血;血液

Example Units

Unit Source
nmol/mL Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=92749-1