9305-4

Mononuclear cells/Leukocytes in Body fluid by Manual count

Active

Term Description

includes lymphocytes and monocytes; reported as % of total WBC

Part Descriptions

LP157588-7   Leukocytes
Leukocytes or white blood cells (WBCs) are immune cells that fight infection, neoplasms and other inflammatory conditions, and mediate allergic responses. There are five types of WBCs normally present in the circulation that are all derived from a similar stem cell in the bone marrow. The five type of WBCs are divided into two groups based on the presence or absence of granules in the cytoplasm. The granulocytes include the neutrophils, basophils and eosinophils. The non-granulocytes include the lymphocytes and the monocytes. The neutrophils fight infection by ingesting and digesting bacteria. Eosinophils and basophils respond to allergic reactions and are capable of ingesting antigen-antibody complexes. Monocytes phagocytose bacteria and release interferon to stimulate the immune system. Lymphocytes are divided into T-cells and B-cells. T-cell immunity is cellular and involves the activation of phagocytes and B-cell immunity uses antibodies to fight infection. Both elevated and low leukocyte counts can be markers of infection and malignancy, and low leukocyte counts are associated with a variety of primary and secondary immunodeficiencies, depending on the WBC type(s) that are out of range. (Mosby's manual of diagnostic and laboratory tests, Kathleen Deska Pagana; Timothy James Pagana, Elsevier St. Louis, Mo ©2010) Source: Regenstrief LOINC

LP17839-9   Mononuclear cells
A Peripheral Blood Mononuclear Cell (PBMC) is a blood cell having a round nucleus, such as a lymphocyte or a monocyte. These blood cells are a critical component in the immune system to fight infection and adapt to intruders. The lymphocyte population consists of T cells (CD4 and CD8 positive ~75%), B cells and NK cells (~25% combined).

These cells are often extracted from whole blood using ficoll, a hydrophilic polysaccharide that separates layers of blood, with monocytes and lymphocytes forming a buffy coat under a layer of plasma. This buffy coat contains the PBMCs. Additionally, PBMC can be extracted from whole blood using a hypotonic lysis which will preferentially lyse red blood cells. This method results in neutrophils and other polymorphonuclear (PMN) cells which are important in innate immune defense to be obtained.

PBMCs are widely used in research and clinical uses every day. HIV research uses them because PBMCs include CD4+ cells, the cells HIV infects. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Mononuclear cell

LP7238-1   Body fld
The LOINC "Body fld" System represents body fluids other than serum, plasma, blood, urine, and cerebrospinal fluid. When a LOINC term with the System "Body fld" is used, the specific specimen source or body fluid type should be reported elsewhere with the result. Where more specific terms for pleural, peritoneal, synovial fluid, etc. exist, we encourage you to use the more specific terms. In contrast to "Body fld", the System "Asp" in LOINC represents the fluid withdrawn during an aspiration procedure from an abnormal collection of fluid, such as from an abscess or cyst. "Asp" is used for abnormal fluid collections that are aspirated, while "Body fld" is used for named body fluids, such as synovial fluid or peritoneal fluid, that are not inherently pathologic. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name

Mononuclear cells/Leukocytes:NFr:Pt:Body fld:Qn:Manual count

Long Common Name

Mononuclear cells/Leukocytes in Body fluid by Manual count

Short Name

Mononuc Cells NFr Fld Manual

Display Name

Mononuclear cells/Leukocytes Manual cnt (Body fld)

Consumer Name Alpha Get Info

Mononuclear cells/White Blood Cells, Body fluid

Part Model Get Info

• Component

  Mononuclear cells/leukocytes
  LP286569-1

  • Analyte

    Mononuclear cells/leukocytes
    LP286569-1

    • Component Numerator

      Mononuclear cells
      LP17839-9

      • Component Numerator Core

        Mononuclear cells
        LP17839-9

      • Component Numerator Core Suffix

        NULL
         

    • Component Denominator

      Leukocytes
      LP157588-7

      • Component Denominator Core

        Leukocytes
        LP157588-7

      • Component Denominator Core Suffix

        NULL
         

  • Challenge

    NULL
     

  • Adjustment

    NULL
     

  • Count

    NULL
     

• Property

  NFr
  LP6838-9

• Time

  Pt
  LP6960-1

  • Time Core

    Pt
    LP6960-1

  • Time Modifier

    NULL
     

• System

  Body fld
  LP7238-1

  • System Core

    Body fld
    LP7238-1

  • Super System

    NULL
     

• Scale

  Qn
  LP7753-9

• Method

  Manual count
  LP6377-8

Basic Attributes

Class

HEM/BC

Type

Laboratory

First Released

Version 1.0i

Last Updated

Version 2.79 (NAM)

Change Reason

Release 2.79: COMPONENT: Triggered by Coll w SCT: This is a specific fraction case where the denominator is percentage or /100. Because the logic is that the percentage piece is captured by Property: NFr (Numeric Fraction), and by Unit: %, therefore, it is redundant to include "100" in the component;

Order vs. Observation

Observation

Common Test Rank Get Info

5093

Language Variants Get Info

Related Names

• B/F
• BF
• bod
• Bodies
• Body fluid
• Body fluid, unsp
• Cell
• Cellularity
• Fl
• Fld
• FLU
• Fluid
• HEMATOLOGY/CELL COUNTS
• Leuc
• Leuk
• Leukocyte
• Lkcs
• Manl
• Mononuc
• Mononuc Cells
• Number Fraction
• Percent
• Point in time
• QNT
• Quan
• Quant
• Quantitative
• Random
• WBC
• WBCs
• White blood cell
• White blood cells

Example Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.

CodeSystem lookup

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=9305-4

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.