93191-5
HTR2C gene c.-759C>T [Genotype] in Blood or Tissue by Molecular genetics method Nominal
Active
Part Descriptions
LP185935-6 HTR2C gene.c.-759C>T
Antidepressant and antipsychotic medication selection may be determined based on a patient's genotype for various polymorphisms within the HTR2A and HTR2C genes, which encode the serotonin (5-hydroxytryptamine) receptors HTR2A and HTR2C. PMID: 15121641 Variants in HTR2A, for example c.102T>C and c.-1438G>A, have been found to affect response to selective serotonin reuptake inhibitors (SSRI) and risk for adverse drug reactions as well as response to the antipsychotic drugs clozapine and aripiprazole. PMID: 14514498, PMID: 10821369 Patients treated with antipsychotics and having significant weight gain have been positively correlated with a polymorphism in the promoter region of HTR2C, c.759C>T, where those with the -759T variant allele showed significantly less weight gain than those without this allele. PMID: 12668355
Source: Regenstrief LOINC
LP40503-2 HTR2C gene
Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. The HTR2C gene, located at Xq24, encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
Source: NCBI Reference Sequence, HTR2C gene
Fully-Specified Name
- Component
- HTR2C gene.c.-759C>T
- Property
- Geno
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Nom
- Method
- Molgen
Additional Names
- Short Name
- HTR2C c.-759C>T Geno Bld/T
- Display Name
- HTR2C gene c.-759C>T genotype Molgen (Bld/Tiss)
- Consumer Name Alpha Get Info
- HTR2C gene c.-759C>T genotype, Blood or tissue specimen
Example Answer List: LL951-5
Source: Laboratory Corporation of America| Answer | Code | Score | Answer ID |
|---|---|---|---|
| C/C (wild type) | LA13521-2 | ||
| C/T (heterozygous) | LA13522-0 | ||
| T/T (homozygous) | LA13523-8 |
Basic Attributes
- Class
- MOLPATH.PHARMG
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.68
- Order vs. Observation
- Observation
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Gen HTR2C c.-759C>T: |
| es-MX | Spanish (Mexico) | Gen HTR2C c.-759C> T: |
| fr-FR | French (France) | HTR2C gène mutation c.-759C>T: |
| it-IT | Italian (Italy) | HTR2C, gene.c.-759C>T: Synonyms: Farmacogenomica Gene HTR2C c.-759C> |
| nl-NL | Dutch (Netherlands) | HTR2C-gen.c.-759C>T: Synonyms: HTR2C gen.c.-759C> |
| zh-CN | Chinese (China) | HTR2C 基因.c.-759C>T: Synonyms: 5HT-1C 5-HT2C 5-HT-2C 5-HTR2C 5-羟基色胺受体 2C 基因 5-羟色胺受体 2C 基因 5-羟色胺受体 2C 基因（5-hydroxytryptamine receptor 2C gene， |
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