93353-1
CD64 Ag [Entitic number] on Neutrophil by Flow cytometry (FC)
Active
Term Description
This term is intended to report the number of CD64 molecules per neutrophil.
Source: Regenstrief LOINC
Part Descriptions
LP268943-0 CD64
CD64, also known as Fc gamma receptor I, is a transmembrane glycoprotein that is part of the large immunoglobulin (Ig) superfamily. CD64 is encoded by 3 genes (FCγRI A-C), one for the transmembrane region and the other 2 for the Ig-like domains. CD64 is consitutively expressed on monocytes and macrophages (but inducible on neutrophils), and it has a pivotal role in antibody-dependent cytotoxicity and clearance of immune complexes. The presence of this molecule on neutrophils can aid in the diagnosis of infection and sepsis, and immuotherapeutic agents targeting CD64 have emerged as candidates for treatment of chronic inflammatory diseases such as atopic dermatitis, rheumatoid arthritis, and autoimmune disorders PMID: 28895912.
Source: Regenstrief LOINC
LP411252-2 Neutrophil
Neutrophils are the most common form of white blood cells in healthy adults. Neutrophils are approximately 13 micrometers in diameter and have segmented nuclei with 3-5 lobes that are connected by thin strands of chromatin. (Practical Haematology; Barbara J. Bain, Imelda Bates, Mike A. Laffan,S. Mitchell Lewis; Eleventh edition; 2012) Neutrophils function to fight infection by both engulfing microorganisms and secreting lethal enzymes.
(https://www.ncbi.nlm.nih.gov/pubmedhealth/PMHT0022058/) They are produced in the bone marrow and their primary function is to fight infection. Neutrophil numbers increase in the blood in response to acute bacterial infection, inflammation, necrosis or chronic myelogenous leukemia. Neutrophil levels are decreased in the following conditions: aplastic anemia, autoimmune disorder, cancer, chemotherapy, myelodysplastic syndrome and during a negative reaction to drugs. PMID: 24050624 [MedlinePlus Encyclopedia:19864]
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- CD64 Ag
- Property
- EntNum
- Time
- Pt
- System
- Neutrophil
- Scale
- Qn
- Method
- Flow cytometry
Additional Names
- Short Name
- CD64 Ag EntNum Neut FC
- Display Name
- CD64 Ag FC (Neutrophil) [Entitic number]
- Consumer Name Alpha Get Info
- CD64 antigen, Neutrophil
Basic Attributes
- Class
- CELLMARK
- Type
- Laboratory
- First Released
- Version 2.67
- Last Updated
- Version 2.67
- Order vs. Observation
- Observation
Member of these Panels
| LOINC | Long Common Name |
|---|---|
| 93354-9 | Neutrophil CD64 and Monocyte HLA DR panel - Blood by Flow cytometry (FC) |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | CD64 Antígeno: Synonyms: Cuantitativo |
| es-MX | Spanish (Mexico) | CD64 Ag: |
| fr-FR | French (France) | CD64 antigène: |
| it-IT | Italian (Italy) | CD64 , Ag: Synonyms: Citometria a flusso (FC) Modelli di superficie cellulare Numero entitico Punto nel tempo (episodio) |
| pl-PL | Polish (Poland) | CD64 Ag: Synonyms: Antygen CD64 CD64 |
| zh-CN | Chinese (China) | CD64 抗原: Synonyms: Ag Fc gamma 受体 I FC gammaRI FC γ RI Fc γ受体 I Fc 受体 I FCR I 中性; |
Example Units
| Unit | Source |
|---|---|
| {#}/{cell} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=93353-1
LOINC Copyright
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