93491-9

AMPAR2 IgG Ab [Presence] in Cerebrospinal Fluid by Cell binding immunofluorescent assay

Active

Part Descriptions

LP229975-0 Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2
Alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptor 1 (AMPAR1) and AMPA receptor 2 (AMPAR2) antibodies target the AMPA receptor, an ionotropic glutamate receptor and key excitatory neurotransmitter. AMPA receptors are comprised of different combinations of four glutamate receptor subunits called GluA1-GluA4 (also known as GluR1-GluR4 and GluR-A to GluR-D). They are vital for brain development and function, such as memory and cognitive development. Detection of antineuronal autoantibodies against AMPA receptors aids in the diagnosis of autoimmune encephalopathies, especially limbic encephalitis, and related conditions. PMCID: PMC4478035 The presence of AMPA antibodies may also indicate an undiscovered tumor in the thymus, lung or breast. PMID: 23983888 The neurological symptoms associated with AMPA receptor 1 antibodies include altered mental status, convulsions, memory loss amnesia, auditory hallucinations, limbic encephalitis, abnormal behavior, schizophrenia, dizziness and hyperthermia. The neurological symptoms associated with AMPA receptor 2 antibodies include seizures, short-term memory loss, limbic encephalitis, altered mental status, chorea and facial dyskinesia. PMID: 24707504 Source: Regenstrief LOINC

LP269367-1 CBA IFA
In cell binding assays or cell-based assays (CBA) also known as cell-based immunoassays, the DNA coding for a particular antigen is transfected into cultured cells, which are then used directly as substrate for antibody detection by immunofluorescence. The advantage of CBA IFA over conventional immunoassays is that purification and stability of the antigen is not required and they provide an in vivo substrate. Source: Regenstrief LOINC,

LOINC Names Get Info

Fully-Specified Name: Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2 Ab.IgG:PrThr:Pt:CSF:Ord:CBA IFA
Long Common Name: AMPAR2 IgG Ab [Presence] in Cerebrospinal Fluid by Cell binding immunofluorescent assay
Short Name: AMPAR2 IgG CSF Ql CBA IFA
Display Name: AMPAR2 IgG Cell binding immunofluorescent assay Ql (CSF)
Consumer Name Alpha Get Info: AMPAR2 IgG antibody, Spinal fluid

Part Model Get Info

Component
Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2 Ab.IgG
LP232464-0
- Analyte
  Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2 Ab.IgG
  LP232464-0
  - Component Numerator
    Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2 Ab.IgG
    LP232464-0
    - Component Numerator Core
      Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2
      LP229975-0
    - Component Numerator Core Suffix
      Ab.IgG
      LP32401-9
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
CSF
LP7156-5
- System Core
  CSF
  LP7156-5
- Super System
  NULL
Scale
Ord
LP7751-3
Method
CBA IFA
LP269367-1

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.67
Last Updated: Version 2.83 (MIN)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
94707-7	Dementia autoimmune Ab panel - Cerebrospinal Fluid
94708-5	Encephalopathy autoimmune Ab panel - Cerebrospinal Fluid
94709-3	Epilepsy autoimmune Ab panel - Cerebrospinal Fluid

Member of these Groups Get Info

LOINC Group	Group Name
LG50935-2	Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor 2 Ab.IgG\|PrThr\|Pt\|CSF

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Alfa-amino-3-hydroxy-5-methyl-4-isoxazolepropionát receptor 2 (AMPAR 2) IgG:Přítomnost nebo práh:Časový bod:Mozkomíšní mok:Ordinální:CBA imunofluorescenční test
el-GR	Greek (Greece)	Υποδοχέας 2 α-αμινο-3-υδροξυ-5-μεθυλο-4-ισοξαζολοπροπιονικού οξέος Αντισώματα IgG:PrThr:Pt:ΕΝΥ:Ord:CBA IFA Synonyms: CBA IFA Ord PrThr Pt SERO Ανοσοσφαιρίνη G Αντίσωμα Αντισώματα IgG ΕΝΥ Υποδοχέας 2 α-αμινο-3-υδροξυ-5-μεθυλο-4-ισοξαζολοπροπιονικού οξέος
es-ES	Spanish (Spain)	Receptor 2 de Alfa-amino-3-hidroxi-5-metil-4-isoxazolepropionato IgG:PrThr:Punto temporal:Líquido Cefalorraquideo:Ord:CBA IFA (inmunofluorescencia indirecta de estudio basqado en células)
es-MX	Spanish (Mexico)	Receptor 2 Ab.IgG de alfa-amino-3-hidroxi-5-metil-4-isoxazolpropionato:Presencia o umbral:Punto temporal:Fluído espinal cerebral:Ordinal:Ensayo inmunofluorescente de unión a células
fr-FR	French (France)	AMPA récepteur 2 Ac IgG:Présence/Seuil:Ponctuel:Liquide céphalorachidien:Qualitatif:Immunofluorescence CBA
it-IT	Italian (Italy)	Recettore tipo 2 per alfa-amino-3-idrossi-5metil-4-isoxazolepropionato Ab.IgG:PrThr:Pt:LCS:Ord:CBA IFA Synonyms: AMPAR2 anticorpi IgG anticorpo Fluorescenza indiretta degli anticorpi (IFA) Liquido cerebrospinale Presenza o Soglia Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
pl-PL	Polish (Poland)	Receptor 2 alfa-amino-3-hydroksy-5-metylo-4-izoksazolopropionowy Ab.IgG:granica wykrywalności:punkt w czasie:płyn mózgowo-rdzeniowy:uporządkowany:test immunofluorescencji pośredniej (z wykorzystaniem komórek) Synonyms: AMPAR2 IgG Przeciwciała do AMPAR2 przeciwciała IgG Przeciwciała IgG do AMPAR2
zh-CN	Chinese (China)	Alpha-氨基-3-羟基-5-甲基-4-异噁唑丙酸受体 2 抗体.IgG:存在情况或阈值:时间点:脑脊液:序数型:CBA IFA Synonyms: Ⅱ Ⅲ Ab.IgG;IgG;抗体 IgG Ab;自身抗体 Alpha-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体 2;α-氨基-3-羟基-5-甲基-4-异唑丙酸受体 2;α-氨基-3-羟基-5-甲基-4-异唑丙酸受体 2;AMPAR2 CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 Hydroxy II III OH α 三依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫球蛋白 G 叁存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间细胞结合分析免疫荧光法;CBA IFA 法羟脊液脊髓液脑脊液（Cerebral spinal fluid，CSF）脑脊髓液血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类间接荧光抗体间接荧光抗体试验阿尔法

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.