Version 2.77

Term Description

Bone marrow or tumor tissue are the common specimens for this test. If these are not available, a blood specimen may be used if there are malignant cells present in the blood (as verified by hematopathology).
Source: Regenstrief LOINC

Part Descriptions

LP411834-7   MYCN gene amplification
MYCN gene amplification studies evaluate the number of copies of the MYCN gene present in a single cell to aid in determining the prognosis of neurobastoma (NBL) patients. The MYCN gene encodes for a protein involved in the formation of tissues and organs during fetal development. It can also be an oncogene that regulates gene transcription. Amplification is determined based on the MYCN gene copy number and MYCN to centromere ratio (CEP2). An MYCN/CEP2 ratio of >= 2.0 is an indication of aggressive tumor progression of neuroblastoma. PMID: 9779703 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

Fully-Specified Name

Component
MYCN gene amplification
Property
Find
Time
Pt
System
Bld/Tiss
Scale
Doc
Method
FISH

Additional Names

Short Name
MYCN amplification Bld/T FISH
Display Name
MYCN gene amplification FISH Doc (Bld/Tiss)
Consumer Name Alpha Get Info
MYCN gene amplification, Blood or tissue specimen

Basic Attributes

Class
MOLPATH
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.68
Change Reason
Release 2.68: SYSTEM: Updated since testing can be done on blood, although bone marrow or tissue is the preferred specimen.
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Amplificación del gen MYCN:Hallazgo:Punto temporal:Sangre o tejido:Doc:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Amplificación del gen MYCN:Hallazgo:Punto temporal:Sangre o tejido:Documento:Hibridación fluorescente in situ (FISH)
fr-FR French (France) MYCN gène amplification:Recherche:Ponctuel:Sang/Tissu:Document:FISH
it-IT Italian (Italy) MYCN, amplificazione gene:Osservazione:Pt:Sangue/Tess:Doc:FISH
Synonyms: Amplificazione del gene MYCN Ibridazione in situ fluorescente (FISH) Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) MYCN-genamplicatie:bevinding:moment:bloed of weefsel:document:FISH
zh-CN Chinese (China) MYCN 基因扩增:发现:时间点:全血/组织:文档型:FISH
Synonyms: Fluorescent in situ hybridization;荧光原位杂交 MYCN 原癌基因, BHLH 转录因子;MYCN Proto-Oncogene, BHLH Transcription Factor 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=93796-1