93797-9

MYCN gene copy number/Chromosome 2 copy number in Tissue by FISH

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Part Descriptions

LP411835-4 MYCN gene copy number
MYCN gene amplification studies evaluate the number of copies of the MYCN gene present in a single cell to aid in determining the prognosis of neurobastoma (NBL) patients. The MYCN gene encodes for a protein involved in the formation of tissues and organs during fetal development. It can also be an oncogene that regulates gene transcription. Amplification is determined based on the MYCN gene copy number and MYCN to centromere ratio (CEP2). An MYCN/CEP2 ratio of >= 2.0 is an indication of aggressive tumor progression of neuroblastoma. PMID: 9779703 Source: Regenstrief LOINC

LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, FISH

LOINC Names Get Info

Fully-Specified Name: MYCN gene copy number/Chromosome 2 copy number:NRto:Pt:Tiss:Qn:FISH
Long Common Name: MYCN gene copy number/Chromosome 2 copy number in Tissue by FISH
Short Name: MYCN copy num/Chr 2 copy num Tiss FISH
Display Name: MYCN copy num/Chromosome 2 copy num FISH (Tiss) [# ratio]
Consumer Name Alpha Get Info: MYCN copy number/Chromosome 2 Copy Number, Tissue

Part Model Get Info

Component
MYCN gene copy number/Chromosome 2 copy number
LP412360-2
- Analyte
  MYCN gene copy number/Chromosome 2 copy number
  LP412360-2
  - Component Numerator
    MYCN gene copy number
    LP411835-4
    - Component Numerator Core
      MYCN gene copy number
      LP411835-4
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Chromosome 2 copy number
    LP411836-2
    - Component Denominator Core
      Chromosome 2 copy number
      LP411836-2
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NRto
LP6840-5
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Tiss
LP7641-6
- System Core
  Tiss
  LP7641-6
- Super System
  NULL
Scale
Qn
LP7753-9
Method
FISH
LP62864-1

Basic Attributes

Class: MOLPATH
Type: Laboratory
First Released: Version 2.67
Last Updated: Version 2.67 (ADD)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gen MYCN počet kopií/Chromozom 2 počet kopií:Početní poměr:Časový bod:Tkáně a stěry:Kvantitativní:Fluorescenční in situ hybridizace (FISH)
el-GR	Greek (Greece)	Αριθμός αντιγράφων γονιδίου MYCN/Αριθμός αντιγράφων χρωμοσώματος 2:NRto:Pt:Ιστός:Qn:Φθορίζουσα υβριδοποίηση in situ Synonyms: MOLPATH NRto Pt Qn Αριθμός Αριθμός αντιγράφων γονιδίου MYCN Αριθμός αντιγράφων χρωμοσώματος 2 Γονίδιο Ιστός Φθορίζουσα υβριδοποίηση in situ Χρωμόσωμα
es-ES	Spanish (Spain)	Número de copias del gen MYCN/Número de copias del cromosoma 2:Relación de número:Punto temporal:Tejido:Qn:Hibridación in situ fluoresente (FISH) Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Número de copia del gen MYCN / número de copia del cromosoma 2:Proporción numérica:Punto temporal:Tejido y frotis:Cuantitativo:Hibridación fluorescente in situ (FISH)
fr-FR	French (France)	MYCN gène nombre de copie/chromosome 2 nombre de copie:Nombre/Nombre:Ponctuel:Tissu:Numérique:FISH
it-IT	Italian (Italy)	MYCN, numero copia gene/Cromosoma 2, numero copia:NRto:Pt:Tessuto:Qn:FISH Synonyms: Ibridazione in situ fluorescente (FISH) Numero copia del cromosoma 2 Numero copia del gene MYCN Patologia molecolare Punto nel tempo (episodio) Rapporto numerico Tessuto & Strisci
pl-PL	Polish (Poland)	Liczba kopii genu MYCN/liczba kopii chromosomu 2:współczynnik liczbowy:punkt w czasie:tkanka i rozmazy:ilościowy:FISH Synonyms: fluorescencyjna hybrydyzacja in situ
zh-CN	Chinese (China)	MYCN 基因拷贝数/染色体 2 拷贝数:计数型比率:时间点:组织与涂片:定量型:FISH Synonyms: Ⅱ Fluorescent in situ hybridization;荧光原位杂交 II MYCN 基因拷贝（副本）数（数量、计数）个数;数目分子病理学;分子病理学试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率时刻;随机;随意;瞬间未作说明的组织;组织;组织 & 涂片染色体 2 拷贝（副本）数（数量、计数）染色体二体型+染色体三体型遗传基因;遗传因子;吉恩;生物基因

Example Units

Unit	Source
{ratio}	Example UCUM Units

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.