94076-7

Mutations/Megabase [# Ratio] in Tumor

Active

Term Description

Tumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy. PMID: 30395155 Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. An ordinal TMB result LOINC 94077-5 of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC.

LOINC Names Get Info

Fully-Specified Name: Mutations/Megabase:NRto:Pt:Tumor:Qn:
Long Common Name: Mutations/Megabase [# Ratio] in Tumor
Short Name: Muts/Mb Tumor
Display Name: Mutations/Megabase (Tumor) [# ratio]
Consumer Name Alpha Get Info: Mutations/Megabase, Tumor

Part Model Get Info

Component
Mutations/megabase
LP411083-1
- Analyte
  Mutations/megabase
  LP411083-1
  - Component Numerator
    Mutations
    LP411082-3
    - Component Numerator Core
      Mutations
      LP411082-3
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Megabase
    LP411120-1
    - Component Denominator Core
      Megabase
      LP411120-1
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NRto
LP6840-5
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Tumor
LP7664-8
- System Core
  Tumor
  LP7664-8
- Super System
  NULL
Scale
Qn
LP7753-9
Method
NULL

Basic Attributes

Class: MOLPATH.MUT
Type: Laboratory
First Released: Version 2.67
Last Updated: Version 2.67 (ADD)
Order vs. Observation: Observation

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Mutace/megabáze:Početní poměr:Časový bod:Tumor:Kvantitativní:
el-GR	Greek (Greece)	Μεταλλάξεις/Μεγαβάση:NRto:Pt:Όγκος:Qn: Synonyms: MOLPATH MOLPATH.MUT NRto Pt Qn Μεγαβάση Μεταλλάξεις Όγκος
es-ES	Spanish (Spain)	Mutaciones/Megabase:Relación de número:Punto temporal:Tumor:Qn: Synonyms: Cuantitativo
es-MX	Spanish (Mexico)	Mutaciones / megabase:Proporción numérica:Punto temporal:Tumor:Cuantitativo:
fr-FR	French (France)	Mutations/mégabase:Nombre/Nombre:Ponctuel:Tumeur:Numérique:
it-IT	Italian (Italy)	Mutazioni/Megabase:NRto:Pt:Tumore:Qn: Synonyms: Mutazione genica Neoplasia Patologia molecolare Punto nel tempo (episodio) Rapporto numerico
zh-CN	Chinese (China)	突变/兆碱基:计数型比率:时间点:肿瘤:定量型: Synonyms: 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变分子病理学;分子病理学试验可用数量表示的;定量性;数值型;数量型;连续数值型标尺同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率时刻;随机;随意;瞬间瘤;肿块;赘生物百万碱基;10^6碱基突变突变类;基因突变

Example Units

Unit	Source
{muts}/{Mb}	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94076-7

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.