Version 2.78

Term Description

Tumor mutation/mutational burden (TMB), also known as mutation load, is a biomarker for various cancer types to identify patients who will benefit from immunotherapy, such as immune checkpoint blockade (ICB) therapy. PMID: 30395155 Various quantitative and ordinal results may be reported, so it is important to distinguish the type of results when mapping to LOINC. Quantitative results typically include the number of mutations detected per megabase (mut/Mb), often by NGS, in a tumor specimen (this term). The mutations targeted may include non-synonymous or both synonymous and non-synonymous mutations. An ordinal TMB result [LOINC: 94077-5] of high, low, etc., may also be reported to provide an overall interpretation for the quantitative value (muts/Mb). We encourage labs to report how results are determined or calculated in either the structured message format or using another LOINC.
Source: Regenstrief LOINC

Fully-Specified Name

Component
Mutations/Megabase
Property
NRto
Time
Pt
System
Tumor
Scale
Qn
Method

Additional Names

Long Common Name
Mutations/Megabase [# Ratio] in Tumor
Short Name
Muts/Mb Tumor
Display Name
Mutations/Megabase (Tumor) [# ratio]
Consumer Name Alpha Get Info
Mutations/Megabase, Tumor

Basic Attributes

Class
MOLPATH.MUT
Type
Laboratory
First Released
Version 2.67
Last Updated
Version 2.67
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Mutaciones/Megabase:Relación de número:Punto temporal:Tumor:Qn:
Synonyms: Cuantitativo
es-MX Spanish (Mexico) Mutaciones / megabase:Proporción numérica:Punto temporal:Tumor:Cuantitativo:
fr-FR French (France) Mutations/mégabase:Nombre/Nombre:Ponctuel:Tumeur:Numérique:
it-IT Italian (Italy) Mutazioni/Megabase:NRto:Pt:Tumore:Qn:
Synonyms: Mutazione genica Neoplasia Patologia molecolare Punto nel tempo (episodio) Rapporto numerico
zh-CN Chinese (China) 突变/兆碱基:计数型比率:时间点:肿瘤:定量型:
Synonyms: 分子病理学.基因突变;分子病理学.突变;分子病理学试验.基因突变;分子病理学试验.突变;分子病理学试验类.突变;基因突变;突变 分子病理学;分子病理学试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率 时刻;随机;随意;瞬间 瘤;肿块;赘生物 百万碱基;10^6碱基 突变 突变类;基因突变

Example Units

Unit Source
{muts}/{Mb} Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94076-7