94188-0
APC gene deletion+duplication and full mutation analysis in Blood or Tissue by Molecular genetics method
Active
Term Description
Full gene sequence analysis is performed to detect the presence of a mutation in all coding regions and intron/exon boundaries of the APC gene. In addition, deletion/duplication analysis, such as by array comparative genomic hybridization (aCGH), is used to test for the presence of large deletions or duplications in the APC gene. This test is used to confirm a diagnosis of familial adenomatous polyposis (FAP) for patients with clinical findings.
Source: Regenstrief LOINC
Part Description
LP19474-3 APC gene
The APC gene (adenomatous polyposis coli) [HGNC Gene ID:583] is located on chromosome 5q21-q22. This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008] [NCBI Gene ID:324]
Source: National Center for Biotechnology Information (NCBI) Gene
Fully-Specified Name
- Component
- APC gene deletion+duplication & full mutation analysis
- Property
- Find
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Doc
- Method
- Molgen
Additional Names
- Short Name
- APC gene Del+Dup + Full Mut Anl Bld/T
- Display Name
- APC gene del+dup and full mutation analysis Molgen Doc (Bld/Tiss)
- Consumer Name Alpha Get Info
- APC gene variant analysis, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH
- Type
- Laboratory
- First Released
- Version 2.68
- Last Updated
- Version 2.68
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
es-ES | Spanish (Spain) | Gen APC estudio delecion+duplicacion y estudio mutacional completo: |
es-MX | Spanish (Mexico) | Eliminación del gen APC + duplicación y análisis de mutación completo: |
fr-FR | French (France) | APC gène délétion+duplication et analyse complète des mutations: |
it-IT | Italian (Italy) | APC, gene Delezione+duplicazione & analisi di mutazione completa: Synonyms: delezione e duplicazione Gene APC Genetica molecolare Osservazione Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & |
nl-NL | Dutch (Netherlands) | APC-gen deletie + duplicatie & volledige mutatie analyse: Synonyms: APC gen molgen |
tr-TR | Turkish (Turkey) | APC geni delesyon+duplikasyon ve tam mutasyon analizi: Synonyms: çiftleme |
zh-CN | Chinese (China) | APC 基因 缺失+重复与全面的突变分析: Synonyms: APC基因; |
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