Version 2.78

Term Description

Flow cytometric immunophenotyping evaluation for presence or absence of the CD11/CD18 complex using monoclonal antibodies directed against the CD11 isoforms, CD11a and CD11b, and CD18 antigens. Defects in CD18 expression lead to either very low or no surface membrane expression of alpha chains CD11a, CD11b, and CD11c. Testing is performed for the diagnosis of leukocyte adhesion deficiency syndrome type 1 (LAD-1), an autosomal recessive disorder caused by mutations in the common chain (CD18) of the beta2-integrin family.
Source: Regenstrief LOINC

Part Descriptions

LP417291-4   CD11a & CD11b & CD18 phenotyping panel
LAD-1 is clinically characterized by recurrent infections, impaired wound healing, delayed umbilical cord separation, persistent leukocytosis, and recurrent soft tissue and oral infections. Each of the beta2-integrins is a heterodimer composed of an alpha chain (CD11a, CD11b, or CD11c) noncovalently linked to a common beta2-subunit (CD18). The alpha-beta heterodimers of the beta2-integrin family include LFA-1 (CD11a/CD18), Mac-1/CR3 (CD11b/CD18), and p150/95 (CD11c/CD18).(1-4) The CD18 gene, ITGB2, and its product are required for normal expression of the alpha-beta heterodimers. Therefore, defects in CD18 expression lead to either very low or no surface membrane expression of CD11a, CD11b, and CD11c. Copyright Copyright © 1995-2009 Source: Mayo Medical Laboratories

LP18359-7   CD11b
Found on myeloid cells and NK-cells
Associated with some AML Source: Regenstrief LOINC

LP20054-0   CD11a
CD11a is found on all leukocytes and may be absent in B-cell neoplasms, including Burkitts lymphoma and Hairy cell leukemia. Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
94266-4 CD11a, CD11b, and CD18 phenotyping panel - Blood Qualitative
Indent94268-0 CD11a cells [Presence] in Blood
Indent94267-2 CD11b cells [Presence] in Blood
Indent94265-6 CD18 cells [Presence] in Blood

Fully-Specified Name

Component
CD11a & CD11b & CD18 phenotyping panel
Property
-
Time
Pt
System
Bld
Scale
Ord
Method

Additional Names

Short Name
CD11a + CD11b + CD18 Pnl Bld
Display Name
CD11a, CD11b, and CD18 phenotyping panel Ql (Bld)
Consumer Name Alpha Get Info
CD11a, CD11b, and CD18 phenotyping panel, Blood

Basic Attributes

Class
PANEL.CELLMARK
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel de fenotipado de CD11a, CD11b y CD18:Propiedades mixtas (sólo paneles):Punto temporal:Sangre:Ord:
es-MX Spanish (Mexico) Panel de fenotipado CD11a y CD11b y CD18:-:Punto temporal:Sangre:Ordinal:
fr-FR French (France) CD11a et CD11b et CD18 phénotypage panel:-:Ponctuel:Sang:Qualitatif:
it-IT Italian (Italy) CD11a & CD11b & CD18, panel fenotipizzazione:-:Pt:Sangue:Ord:
Synonyms: Modelli di superficie cellulare Panel fenotipizzazione CD11a, CD11b, e CD18 Punto nel tempo (episodio) Sangue Set di prescrizione per marcatore cellulare
nl-NL Dutch (Netherlands) CD11a & CD11b & CD18 fenotypering panel:-:moment:bloed:ordinaal:
pl-PL Polish (Poland) CD11a & CD11b & CD18, panel fenotypujący:-:punkt w czasie:krew:półilościowy:
Synonyms: CD11a CD11a & CD11b & CD18, panel fenotypujący CD11b CD18
zh-CN Chinese (China) CD11a 与 CD11b 与 CD18 表现型分型组套:-:时间点:全血:序数型:
Synonyms: AlphaL 整合素链 AlphaL 整合素链（AlphaL integrin chain） AlphaM 整合素链 AlphaM 整合素链（AlphaM integrin chain） AlphaM-beta2 Beta2;Beta-2 整合素;Beta-2 整合素链;CD11a beta 亚单位;CD11a beta 亚基;CD11a β亚单位;CD11a β亚基;CD11b beta 亚单位;CD11b beta 亚基;CD11b β亚单位;CD11b β亚基;CD11c beta 亚单位;CD11c beta 亚基;CD11c β亚单位;CD11c β亚基;β-2 整合素;β-2 整合素链;发现于所有白细胞之上；与某些 B-细胞肿瘤相关；在白细胞粘附缺陷（leukocyte adhesion deficie C3biR CD11a 与 CD11b 与 CD18 表现型分型（表型分型、表现型分析、表型分析）组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） CR3 Integrin alpha M;ITGAM;整合素αM;CR3A;cluster of differentiation molecule 11B;CD11B;分化抗原簇 11B;分化簇 11B;MAC-1;MAC1A;MO1A;SLEB6 Integrin, alpha L;整合素αL;ITG αL;antigen CD11A;抗原 CD11A;p180;lymphocyte function-associated antigen 1;淋巴细胞功能相关抗原 1;alpha polypeptide;alpha 多肽;α多肽;ITGAL Leu15 Leu-15 LFA-1alpha Mac-1 Mo1 R3 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.细胞标志物;组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）类.细胞标志物;实验室医嘱组类.细胞标志物;细胞标志物医嘱组;细胞标志物医嘱组类 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 组 组合 组合医嘱 组合类 组套 细胞标志物 血;血液 表型分型 表型分析 表型鉴定 表现型分析

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94266-4
Questionnaire definition
https://fhir.loinc.org/Questionnaire/?url=http://loinc.org/q/94266-4