Version 2.78

Term Description

The patient's genotype for the c.253G>T (rs1902023) variant in the UGT2B15 gene. Patients with genotype TT, for example, reportedly have a decreased clearance of lorazepam. PMID: 15961980[PharmGKB Variant ID: 769169595]
Source: Regenstrief LOINC

Part Description

LP417574-3   UGT2B15 gene.c.253G>T
The UGT2B15 gene (UDP glucuronosyltransferase 2 family, polypeptide B15) [HGNC Gene ID:12546] is located on chromosome 4q13. This gene encodes a member of the UDP-glycosyltransferase (UDPGT) family. The UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This protein displays activity towards several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens. [provided by RefSeq, Oct 2011] [NCBI Gene ID:7366] Source: National Center for Biotechnology Information (NCBI) Gene

Fully-Specified Name

Component
UGT2B15 gene.c.253G>T
Property
Geno
Time
Pt
System
Bld/Tiss
Scale
Nom
Method
Molgen

Additional Names

Short Name
UGT2B15 c.253G>T Geno Bld/T
Display Name
UGT2B15 gene c.253G>T genotype Molgen (Bld/Tiss)
Consumer Name Alpha Get Info
UGT2B15 gene c.253G>T genotype, Blood or tissue specimen

Example Answer List: LL3630-2

Source: Regenstrief LOINC
Answer Code Score Answer ID
G/G (wild type) LA19932-5
G/T (heterozygous) LA24047-5
T/T (homozygous) LA13523-8

Basic Attributes

Class
MOLPATH.PHARMG
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Observation

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Gen UGT2B15 c.253G> T:Genotipo:Punto temporal:Sangre o tejido:Nom:Genética molecular
es-MX Spanish (Mexico) Gen UGT2B15 c.253G> T:Genotipo:Punto temporal:Sangre o tejido:Nominal:Genética molecular
fr-FR French (France) UGT2B15 gène mutation c.253G>T:Génotype:Ponctuel:Sang/Tissu:Résultat nominal:Biologie moléculaire
it-IT Italian (Italy) UGT2B15, gene.c.253G>T:Geno:Pt:Sangue/Tess:Nom:Molgen
Synonyms: Farmacogenomica Gene UGT2B15 Genetica molecolare Genotipo Patologia molecolare Punto nel tempo (episodio) Sangue Sangue o Tessuto Tessuto & Strisci UGT2B15, gene c.253G>T
nl-NL Dutch (Netherlands) UGT2B15-gen c.253G>T:genotype:moment:bloed of weefsel:nominaal:moleculair genetisch onderzoek
Synonyms: molgen
zh-CN Chinese (China) UGT2B15 基因.c.253G>T:基因型:时间点:全血/组织:名义型:分子遗传学类实验室方法
Synonyms: C 型;丙;丙型 全血或组织;血液/组织;血液或组织 分子病理学;分子病理学试验 分子遗传学;分子遗传学方法;分子遗传学类方法;分子遗传学类检验方法;包括 RFL、PCR 及其他方法在内，用于在分子基础上检测遗传属性的方法的大类;聚合酶链反应;聚合酶链式反应 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 尿苷二磷酸葡萄糖醛酸基转移酶 2 家族, 多肽 B15;UDP 葡萄糖醛酸基转移酶 2 家族, 多肽 B15;UGT 2 家族, 多肽 B15;UDP 葡萄糖醛酰基转移酶 2 家族, 多肽 B15;UDP 葡萄糖苷酸基转移酶 2 家族, 多肽 B15;UDP 葡萄糖苷酰转移酶 2 家族, 多肽 B15;UDP glucuronosyltransferase 2 family, polypeptide B15 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

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CodeSystem lookup
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