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Term Description

Laboratories that perform HLA antibody testing often report the specific antibodies found in categories based on the "amount" of each antibody found (called mean fluorescent intensity, MFI, for the common Luminex bead method). Theoretically, the antibodies present in higher concentrations, which are more likely to react with donor antigens, will have higher MFI values. Since risk stratification based on MFI range is not standardized and the exact cutoffs vary from lab to lab, this term is intended to report those HLA antibodies found in the higher risk stratification of MFI values (For one lab this was MFI > 5000, but some laboratories use 10,000 or another value).

Part Description

LP417656-8   HLA-DP & DQ & DR (class II) Ab.IgG high risk
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.

Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name
HLA-DP & DQ & DR (class II) Ab.IgG high risk:Prid:Pt:Ser/Plas:Nom:Flow cytometry
Long Common Name
HLA-DP and DQ and DR (class II) IgG high risk [Identifier] in Serum or Plasma by Flow cytometry (FC)
Short Name
HLA class II Ab.IgG high risk SerPl FC
Display Name
HLA-DP & DQ & DR (class II) Ab.IgG high risk FC Nom
Consumer Name Alpha Get Info
HLA-DP & DQ & DR (class II) Ab.IgG high risk, Blood

Part Model Get Info

  • Component
    HLA-DP & DQ & DR (class II) Ab.IgG high risk
    LP417656-8
    • Analyte
      HLA-DP & DQ & DR (class II) Ab.IgG high risk
      LP417656-8
      • Component Numerator
        HLA-DP & DQ & DR (class II) Ab.IgG high risk
        LP417656-8
        • Component Numerator Core
          HLA-DP & DQ & DR (class II) Ab.IgG high risk
          LP417656-8
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Prid
    LP6850-4
  • Time
    Pt
    LP6960-1
  • System
    Ser/Plas
    LP7576-4
    • System Core
      Ser/Plas
      LP7576-4
    • Super System
      NULL
       
  • Scale
    Nom
    LP7750-5
  • Method
    Flow cytometry
    LP6274-7

Example Answer List: LL3602-1

Source: NCBI PubMed
AnswerCodeScoreAnswer ID
Anti-DP1LA23895-8
Anti-DP2LA23894-1
Anti-DP3LA23897-4
Anti-DP4LA23896-6
Anti-DP5LA23898-2
Anti-DP6LA23899-0
Anti-DQ1LA23909-7
Anti-DQ2LA23906-3
Anti-DQ3LA23907-1
Anti-DQ4LA23908-9
Anti-DQ5(1)LA23903-0
Anti-DQ6(1)LA23902-2
Anti-DQ7(3)LA23904-8
Anti-DQ8(3)LA23905-5
Anti-DR1LA23910-5
Anti-DR3LA23914-7
Anti-DR4LA23915-4
Anti-DR6LA23922-0
Anti-DR7LA23916-2
Anti-DR8LA23917-0
Anti-DR10LA23918-8
Anti-DR11(5)LA23919-6
Anti-DR12(5)LA23920-4
Anti-DR13(6)LA23921-2
Anti-DR14(6)LA23923-8
Anti-DR15(2)LA23924-6
Anti-DR16(2)LA23925-3
Anti-DR17(3)LA23912-1
Anti-DR18(3)LA23913-9
Anti-DR51LA23927-9
Anti-DR52LA23926-1
Anti-DR53LA23928-7
Anti-DR103LA23911-3

Basic Attributes

Class
HLA
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68 (ADD)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
94428-0HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC)
94440-5HLA-DP and DQ and DR (class II) IgG panel - Serum or Plasma by Flow cytometry (FC)

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)HLA-DP a DQ a DR (třída II) IgG vysoké riziko:Přítomnost nebo identita:Časový bod:Sérum/plazma:Nominální:Průtoková cytometrie
el-GRGreek (Greece)Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP & DQ & DR (Κατηγορία IΙ) Αντισώματα IgG υψηλού κινδύνου:Prid:Pt:Ορός/Πλάσμα:Nom:Κυτταρομετρία ροής
Synonyms: dP Nom Prid Pt Ανθρώπινα λευκοκυτταρικά αντιγόνα Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP & DQ & DR (Κατηγορία II) Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP & DQ & DR (Κατηγορία IΙ) Αντισώματα IgG υψηλού κινδύνου Ανθρώπινα λευκοκυτταρικά αντιγόνα-DP+DQ+DR Ανοσοσφαιρίνη G Κατηγορία Κυτταρομετρία ροής Ορός Ορός/Πλάσμα Πλάσμα
es-ESSpanish (Spain)HLA-DP, DQ, DR (CLASE II) alto riesgo por Ac IgG:Presencia o identidad:Punto temporal:Suero o Plasma:Nom:Citometria de flujo (FC)
es-MXSpanish (Mexico)HLA-DP & DQ & DR (clase II) Ab.IgG alto riesgo:Presencia o identidad:Punto temporal:Suero o Plasma:Nominal:Citometría de flujo (FC)
fr-FRFrench (France)HLA-DP et DQ et DR (classe II) anticorps IgG MFI forte:Identification:Ponctuel:Sérum/Plasma:Résultat nominal:Cytométrie de flux
it-ITItalian (Italy)HLA-DP & DQ & DR (classe II) Ab.IgG, rischio elevato:Prid:Pt:Siero/Plasma:Nom:Citometria a flusso
Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-DP e DQ e DR (classe II) Plasma Presenza o Identità Pressione differenziale Punto nel tempo (episodio) Rischio elevato di HLA-DP & DQ & DR (classe II) Ab.IgG Siero Siero o Plasma
nl-NLDutch (Netherlands)HLA-DP & DQ & DR (klasse II) As.IgG hoog risico:identificator:moment:serum of plasma:nominaal:flowcytometrie
pl-PLPolish (Poland)HLA-DP & DQ & DR (klasa II) Ab.IgG wysokiego ryzyka:obecność lub identyfikacja:punkt w czasie:surowica lub osocze:skala nominalna:cytometria przepływowa (FC)
Synonyms: HLA-DP i DQ i DR (klasa II) HLA-DP, DQ i DR IgG Przeciwciała IgG do HLA-DP, DQ i DR (klasa II) Przeciwciała IgG do HLA-DP, DQ i DR (klasa II) wysokiego ryzyka wynik kategorialny
zh-CNChinese (China)HLA-DP 与 DQ 与 DR (II 类) 抗体.IgG 高度风险:存在与否或特征标识:时间点:血清/血浆:名义型:流式细胞测量术
Synonyms: HLA II 类;II 类 HLA HLA 抗原;人类白细胞抗原;human leukocyte antigen HLA-DP 与 DQ 与 DR (II 类) 抗体（Ab）.IgG 高度风险（高危、高风险、高等风险）;人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA HLA-DP 与 DQ 与 DR (II 类);人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA 人白细胞抗原 人类白细胞抗原 人类白细胞抗原（Human Leukocyte Antigen，HLA） 免疫球蛋白 G 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 动态 存在;存在与否;特征标识;身份;身份标识 族;种类;等;类;类别;级;纲;组 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 白细胞抗原 血清或血浆

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94447-0