Version 2.78

Term Description

Laboratories that perform HLA antibody testing often report the specific antibodies found in categories based on the "amount" of each antibody found (called mean fluorescent intensity, MFI, for the common Luminex bead method). Theoretically, the antibodies present in higher concentrations, which are more likely to react with donor antigens, will have higher MFI values. Since risk stratification based on MFI range is not standardized and the exact cutoffs vary from lab to lab, this term is intended to report those HLA antibodies found in the higher risk stratification of MFI values (For one lab this was MFI > 5000, but some laboratories use 10,000 or another value).
Source: Regenstrief LOINC

Part Description

LP417652-7   HLA-A & B & C (class I) Ab.IgG high risk
The major histocompatibility complex (MHC) class I (A, B, and C) and II (DP, DM, DOA, DOB, DQ, and DR) in the human leukocyte antigen (HLA) system contains a large number of genes involved in immune system function in humans. The proteins encoded by some genes form antigens. HLA class I and II antigens are widely distributed on all nucleated cells and carried by platelets.

Antibodies specific to HLA class I and II antigens can be acquired through alloimmunization due to pregnancy, transfusion of blood products, or previous transplants. Alloimmunization can lead to production of antibodies in approximately one third of individuals. The presence of antibodies, specifically IgG, can affect the survival of transplant allografts or transfused platelets in sensitized individuals. Various testing methods are used to detect antibodies to HLA antigens. Source: Regenstrief LOINC

Fully-Specified Name

Component
HLA-A & B & C (class I) Ab.IgG high risk
Property
Prid
Time
Pt
System
Ser/Plas
Scale
Nom
Method
Flow cytometry

Additional Names

Short Name
HLA class I Ab.IgG high risk SerPl FC
Display Name
HLA-A & B & C (class I) Ab.IgG high risk FC Nom
Consumer Name Alpha Get Info
HLA-A & B & C (class I) Ab.IgG high risk, Blood

Example Answer List: LL5520-3

Source: NCBI PubMed
Answer Code Score Answer ID
Anti-A1 LA23858-6
Anti-A2 LA23859-4
Anti-A3 LA23860-2
Anti-A9 LA23861-0
Anti-A11 LA23863-6
Anti-A28 LA23864-4
Anti-A29 LA23865-1
Anti-B7 LA23870-1
Anti-B12 LA23872-7
Anti-B13 LA23873-5
Anti-B22 LA23876-8
Anti-B27 LA23877-6
Anti-B35 LA23878-4
Anti-B41 LA23880-0
Anti-Cw1 LA23886-7
Anti-Cw4 LA23888-3
Anti-Cw5 LA23889-1
Anti-Cw3 LA23890-9
Anti-Cw7 LA23892-5

Basic Attributes

Class
HLA
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
94428-0 HLA class I and II IgG panel - Serum or Plasma by Flow cytometry (FC)
94446-2 HLA-A and B and C (class I) IgG panel - Serum or Plasma by Flow cytometry (FC)

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) HLA-A, B, C (clase I) alto riesgo por Ac IgG:Presencia o identidad:Punto temporal:Suero o Plasma:Nom:Citometria de flujo (FC)
es-MX Spanish (Mexico) HLA-A & B & C (clase I) Ab.IgG alto riesgo:Presencia o identidad:Punto temporal:Suero o Plasma:Nominal:Citometría de flujo (FC)
fr-FR French (France) HLA-A et B et C (classe I) anticorps IgG MFI forte:Identification:Ponctuel:Sérum/Plasma:Résultat nominal:Cytométrie de flux
it-IT Italian (Italy) HLA-A & B & C (classe I) Ab.IgG, rischio elevato:Prid:Pt:Siero/Plasma:Nom:Citometria a flusso
Synonyms: Citometria a flusso (FC) HLA tipizzazione tissutale antigeni-anticorpi HLA-A e B e C (classe I) Plasma Presenza o Identità Punto nel tempo (episodio) Rischio elevato di HLA-A & B & C (classe I) Ab.IgG Siero Siero o Plasma
nl-NL Dutch (Netherlands) HLA A & B & C (klasse I) As.IgG hoog risico:identificator:moment:serum of plasma:nominaal:flowcytometrie
pl-PL Polish (Poland) HLA-A & B & C (klasa I) Ab.IgG wysokiego ryzyka:wykrycie lub identyfikacja:punkt w czasie:surowica lub osocze:cecha:cytometria przepływowa (FC)
Synonyms: IgG Przeciwciała do antygenu I układu grupowego krwi Ii Przeciwciała IgG do HLA-A, B i C (klasa I) Przeciwciała IgG do HLA-A, B i C (klasa I) wysokiego ryzyka
zh-CN Chinese (China) HLA-A 与 B 与 C (I 类) 抗体.IgG 高度风险:存在与否或特征标识:时间点:血清/血浆:名义型:流式细胞测量术
Synonyms: A 型 A,B 型;AB 型 B 型 C 型;丙;丙型 HLA I 类;I 类 HLA HLA 抗原;人类白细胞抗原;human leukocyte antigen HLA-A 与 B 与 C (I 类) 抗体（Ab）.IgG 高度风险（高危、高风险、高等风险）;人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA I 型 I 型抗体 人白细胞抗原 人类白细胞抗原 人类白细胞抗原（Human Leukocyte Antigen，HLA） 人类白细胞抗原;人白细胞抗原;human leukocyte antigen;HLA 免疫球蛋白 G 分类型应答;分类型结果;名义性;名称型;名词型;名词性;标称性;没有自然次序的名义型或分类型应答 动态 存在;存在与否;特征标识;身份;身份标识 族;种类;等;类;类别;级;纲;组 时刻;随机;随意;瞬间 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 白细胞抗原 血清或血浆

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94449-6