Version 2.73

94704-4Voltage-gated calcium channel N type binding Ab [Moles/volume] in Serum by ImmunoassayActive

Part Description

LP40153-6   Voltage-gated calcium channel N type binding Ab
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterised by muscle weakness of the limbs. It is the result of an autoimmune reaction, where antibodies are formed against presynaptic voltage-gated calcium channels in the neuromuscular junction (the connection between nerves and the muscle that they supply). Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body).

In LEMS, antibodies against voltage-gated calcium channels (VGCC), particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be mobilized to the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5-S6 linker peptide". Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, a protein involved in calcium-regulated vesicle transport, rather than against VGCC. Many people with LEMS, both with and without VGCC antibodies, have detectable antibodies against the M1 subtype of the acetylcholine receptor; it is thought that their presence participates in a lack of compensation for the slow calcium influx. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Voltage-gated calcium channel N type binding Ab

Additional Names

Short Name
VGCC-N Bind Ab Ser IA-sCnc
Display Name
Voltage-gated calcium channel N type binding Ab IA (S) [Moles/Vol]
Consumer Name Alpha
Voltage-gated Calcium Channel N Type Binding antibody, Blood

Basic Attributes

First Released
Version 2.68
Last Updated
Version 2.68
Order vs. Observation

Member of these Groups

LG50991-5 Voltage-gated calcium channel N type binding Ab|SCnc|Pt|ANYBldSerPl

Language Variants Get Info

zh-CNChinese (China)
N 型电压门控钙离子通道结合 抗体:物质的量浓度:时间点:血清:定量型:免疫测定法
nl-NLDutch (Netherlands)
voltage-gated calciumkanaal N type binding As:mol/volume:moment:serum:kwantitatief:immunoassay
fr-BEFrench (Belgium)
Fixation canal calcique type N voltage-dépendant Ac:Concentration de substance:Temps ponctuel:Sérum:Quantitatif:IA
fr-CAFrench (Canada)
Fixation canal calcique type N voltage-dépendant , Ac:Concentration de substance:Temps ponctuel:Sérum:Quantitatif:IA
fr-FRFrench (France)
Canaux calciques voltage dépendants type N anticorps:Moles/Volume:Ponctuel:Sérum:Numérique:Immunoanalyse
it-ITItalian (Italy)
Canale del calcio voltaggio-dipendente di tipo N, legante Ab:SCnc:Pt:Siero:Qn:IA
ru-RURussian (Russian Federation)
Потенциал-зависимый кальциевый канал N тип связывающий Ат:МолКонц:ТчкВрм:Сыв:Колич:IA
es-MXSpanish (Mexico)
Ab ligante del tipo N del canal de calcio dependiente de voltaje:Concentración de sustancias:Punto temporal:Suero:Cuantitativo:Inmunoensayo
es-ESSpanish (Spain)
Canales de calcio dependientes de voltaje tipo N Anticuerpos:Concentración de sustancia:Punto temporal:Suero:Qn:IA
tr-TRTurkish (Turkey)
Voltaj kapılı kalsiyum channel N tip bağlayıcı Ab:SubKons:Zmlı:Ser:Kant:İA

Example Units

Unit Source
nmol/L Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info