Version 2.77

Term Description

Qualitative detection of human neutrophil peptide-1, -2, and -3, also known as alpha defensins 1-3, in synovial fluid by immunoassay methods, such as ELISA or lateral flow assay, for the diagnosis of periprosthetic joint infections (PJI). This assay detects but does not differentiate between the three HNP peptides. This term was created for, but not limited in use to, Zimmer Biomet Diagnostics Synovasure Alpha Defensin ELISA and Lateral Flow Test kits. The Synovasure Lateral flow test utilizes the same anti-microbial peptide as the ELISA test to detect the immune response to infection, but the Lateral Flow returns results in 10 minute whereas the ELISA typically has a 24-48 hour result turnaround.
Source: Regenstrief LOINC

Part Description

LP417746-7   Alpha defensins 1+2+3
Human neutrophil peptides (HNPs), also known as alpha defensins, are antimicrobial peptides released by activated neutrophils in response to infection. HNP-1 and HNP-2 are encoded by the DEFA1 gene, and HNP-3 is encoded by DEFA3 gene. All three peptides are nearly identical; they only differ by the first amino acid in their sequence. HNPs have antibacterial, fungicide and antiviral activities. PMID: 15616305 They have been extensively studied as a biomarker in various diseases such as infections, atherosclerosis, rheumatic diseases, preeclampsia, and cancer. PMID: 16513165 PMID: 19186224 PMID: 25196784 HNP synovial fluid proteins are used as a diagnostic biomarker for periprosthetic joint infection (PJI). PMID: 31856885 Source: Regenstrief LOINC

Fully-Specified Name

Component
Alpha defensins 1+2+3
Property
PrThr
Time
Pt
System
Synv fld
Scale
Ord
Method
IA

Additional Names

Short Name
Alpha defensins 1+2+3 Snv Ql IA
Display Name
Alpha defensins 1+2+3 IA Ql (Syn fld)
Consumer Name Alpha Get Info
Alpha defensins 1+2+3, Synovial fluid

Example Answer List: LL2021-5

Source: Gen-Probe
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6
InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value) LA15841-2

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.72
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Alfa defensinas 1+2+3:PrThr:Punto temporal:Líquido sinovial:Ord:IA
es-MX Spanish (Mexico) Alfa defensinas 1 + 2 + 3:Presencia o umbral:Punto temporal:Líquido sinovial:Ordinal:Inmunoensayo
fr-FR French (France) Alpha défensines 1+2+3:Présence/Seuil:Ponctuel:Liquide synovial:Qualitatif:Immunoanalyse
it-IT Italian (Italy) Alfa defensine 1+2+3:PrThr:Pt:Liquido sinoviale:Ord:IA
Synonyms: Chimica Immunoassay Presenza o Soglia Punto nel tempo (episodio)
nl-NL Dutch (Netherlands) alfa-defensine 1 + 2 + 3:aanwezigheid:moment:synoviaal vocht:ordinaal:immunoassay
Synonyms: IA
zh-CN Chinese (China) Alpha 防御素 1+2+3:存在情况或阈值:时间点:滑液:序数型:免疫测定法
Synonyms: Ⅰ Ⅱ Ⅲ I II III α α防御素 1+2+3;Alpha 防卫素 1+2+3;α防卫素 1+2+3 三 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 关节吸出液;关节抽出液;关节液;骨膜液;滑膜腔积液;关节腔积液 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 叁 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 阿尔法

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94718-4