Alpha defensins 1+2+3 [Presence] in Synovial fluid by Immunoassay
Qualitative detection of human neutrophil peptide-1, -2, and -3, also known as alpha defensins 1-3, in synovial fluid by immunoassay methods, such as ELISA or lateral flow assay, for the diagnosis of periprosthetic joint infections (PJI). This assay detects but does not differentiate between the three HNP peptides. This term was created for, but not limited in use to, Zimmer Biomet Diagnostics Synovasure Alpha Defensin ELISA and Lateral Flow Test kits. The Synovasure Lateral flow test utilizes the same anti-microbial peptide as the ELISA test to detect the immune response to infection, but the Lateral Flow returns results in 10 minute whereas the ELISA typically has a 24-48 hour result turnaround.
Source: Regenstrief LOINC
LP417746-7 Alpha defensins 1+2+3
Human neutrophil peptides (HNPs), also known as alpha defensins, are antimicrobial peptides released by activated neutrophils in response to infection. HNP-1 and HNP-2 are encoded by the DEFA1 gene, and HNP-3 is encoded by DEFA3 gene. All three peptides are nearly identical; they only differ by the first amino acid in their sequence. HNPs have antibacterial, fungicide and antiviral activities. PMID: 15616305 They have been extensively studied as a biomarker in various diseases such as infections, atherosclerosis, rheumatic diseases, preeclampsia, and cancer. PMID: 16513165 PMID: 19186224 PMID: 25196784 HNP synovial fluid proteins are used as a diagnostic biomarker for periprosthetic joint infection (PJI). PMID: 31856885 Source: Regenstrief LOINC
- Alpha defensins 1+2+3
- Synv fld
- Short Name
- Alpha defensins 1+2+3 Snv Ql IA
- Display Name
- Alpha defensins 1+2+3 IA Ql (Syn fld)
- Consumer Name Alpha Get Info
- Alpha defensins 1+2+3, Synovial fluid
Example Answer List: LL2021-5Source: Gen-Probe
|PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)||LA6576-8|
|NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)||LA6577-6|
|InvalidCopyright http://snomed.info/sct ID:455371000124106 Invalid result (qualifier value)||LA15841-2|
- First Released
- Version 2.68
- Last Updated
- Version 2.72
- Order vs. Observation
Language Variants Get Info
|es-ES||Spanish (Spain)||Alfa defensinas 1+2+3:
|es-MX||Spanish (Mexico)||Alfa defensinas 1 + 2 + 3:
|fr-FR||French (France)||Alpha défensines 1+2+3:
|it-IT||Italian (Italy)||Alfa defensine 1+2+3:
Synonyms: Chimica Immunoassay Presenza o Soglia Punto nel tempo (episodio)
|nl-NL||Dutch (Netherlands)||alfa-defensine 1 + 2 + 3:
|zh-CN||Chinese (China)||Alpha 防御素 1+2+3:
Synonyms: Ⅰ Ⅱ Ⅲ I II III α α防御素 1+2+3;
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