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Part Description

LP418389-5   Transthyretin
Transthyretin (TTR) (originally called prealbumin or thyroxine-binding prealbumin) is a homotetrameric unglycosylated tryptophan rich protein that carries the thyroid hormones T3 and T4, and retinol in serum and CSF. Synthesized in hepatocytes, TTR and has a molar mass of 55000 daltons. At a pH of 8.6, an electrophoretic band appears prior to albumin in a relative amount of < 2.5 % due to its greater rate of diffusion to the anode. Its function is to bind and transport low molecular weight retinol-binding proteins, preventing their glomerular filtration. 30 50 % of circulating TTR is complexed by retinol-binding protein. Additionally, it binds and transports thyroxine (T4), nevertheless its affinity to this hormone is less than that of thyroxine binding globulin. TTR is decreased in hepatocellular synthesis caused by acute liver damage, or dietary protein deficiency, and because of its short half life (approximately 2 days) is used as a surrogate marker of nutritional status. TTR is also a negative acute phase reactive protein and levels decrease in inflammatory states. Levels can be elevated in chronic renal failure, high concentrations of corticosteroids, and Hodgkin's disease. TTR misfolding and aggregation is known to be associated with the amyloid diseases, senile systemic amyloidosis (SSA), familial amyloid polyneuropathy (FAP), and familial amyloid cardiomyopathy (FAC) [Tietz] Source: Regenstrief LOINC, Wikipedia: Transthyretin

LOINC Names Get Info

Fully-Specified Name
Transthyretin:Mass:Pt:Bld:Qn:
Long Common Name
Transthyretin [Mass] in Blood
Short Name
TTR Bld Qn
Display Name
Transthyretin (Bld) [Mass]
Consumer Name Alpha Get Info
Transthyretin, Blood

Part Model Get Info

  • Component
    Transthyretin
    LP418389-5
    • Analyte
      Transthyretin
      LP418389-5
      • Component Numerator
        Transthyretin
        LP418389-5
        • Component Numerator Core
          Transthyretin
          LP418389-5
        • Component Numerator Core Suffix
          NULL
           
      • Component Denominator
        NULL
         
        • Component Denominator Core
          NULL
           
        • Component Denominator Core Suffix
          NULL
           
    • Challenge
      NULL
       
    • Adjustment
      NULL
       
    • Count
      NULL
       
  • Property
    Mass
    LP6826-4
  • Time
    Pt
    LP6960-1
  • System
    Bld
    LP7057-5
    • System Core
      Bld
      LP7057-5
    • Super System
      NULL
       
  • Scale
    Qn
    LP7753-9
  • Method
    NULL
     

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68 (ADD)
Order vs. Observation
Observation

Member of these Panels

LOINCLong Common Name
94864-6Transthyretin-associated familial amyloidosis panel - Blood

Language Variants Get Info

TagLanguageTranslation
cs-CZCzech (Czechia)Transthyretin:Hmotnost:Časový bod:Krev:Kvantitativní:
el-GRGreek (Greece)Τρανσθυρετίνη:Mass:Pt:Αίμα:Qn:
Synonyms: CHEM Mass Pt Qn Αίμα Τρανσθυρετίνη
es-ESSpanish (Spain)Transtiretina:Masa:Punto temporal:Sangre:Qn:
Synonyms: Cuantitativo
es-MXSpanish (Mexico)Transtiretina:Masa:Punto temporal:Sangre:Cuantitativo:
fr-FRFrench (France)Transthyrétine:Masse:Ponctuel:Sang:Numérique:
it-ITItalian (Italy)Transtiretina:Massa:Pt:Sangue:Qn:
Synonyms: Chimica Punto nel tempo (episodio) Sangue
nl-NLDutch (Netherlands)transthyretine:massa:moment:bloed:kwantitatief:
pl-PLPolish (Poland)Transtyretyna:masa:punkt w czasie:krew:ilościowy:
zh-CNChinese (China)甲状腺素视黄质运载蛋白:质量:时间点:全血:定量型:
Synonyms: TTR; 甲状腺素结合前清蛋白;thyroxine binding prealbumin;TBPA;转甲状腺素蛋白;甲状腺素运载蛋白;甲状腺素运送蛋白 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 血;血液 重量

Example Units

UnitSource
uExample UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=94860-4