94870-3

Ganglioside GD1b IgM Ab [Presence] in Serum by Immunoassay

Active

Part Descriptions

LP14394-8 Ganglioside GD1b
Gangliosides are a family of molecules that are present throughout the body but especially prevalent in cells of the nervous system. Specific gangliosides are named for the carbohydrate sequence they contain and have a unique distribution within the nervous system. The oligosaccharide groups on gangliosides act as cell surface markers that play a role in cellular recognition and cell-to-cell communication, and they also act as specific receptors for certain pituitary glycoprotein hormones and certain bacterial protein toxins such as cholera toxin.
Anti-ganglioside antibodies, primarily IgG, are present in the sera from approximately 60% of patients with Guillain-Barré syndrome (GBS), and antibodies against different gangliosides are associated with different forms of GBS.
1. Antibodies against GD1a/GD1b and GD1b/GT1b complexes have been found in patients with more severe GBS requiring mechanical ventilation;
2. Antibodies against GM1 or those against GalNAc-GD1a have been associated with acute motor axonal neuropathy;
3. Anti-GQ1b antibodies are specifically associated with a variant of GBS called Fisher syndrome, which is characterized by ophthalmoplegia and ataxia.
Detection of specific markers early in the course of GBS may help guide the plan of care. PMID: 21214559 Source: Regenstrief LOINC, PMID: 2121455

LP222219-0 Ganglioside
A ganglioside molecule consists of a glycosphingolipid (ceramide and oligosaccharide) with one or more sialic acid residues linked to the sugar chain. Molecules with one sialic acid residue are called monosialogangliosides (GM), those with two are called disialogangliosides (GD), and those with three are trisialogangliosides (GT). Gangliosides without any sialic acid residues are called asialogangliosides, while those that do not have a ceramide N-acyl group are called lysogangliosides. The number that typically is included at the end of the name indicates the order in which the molecule was discovered. For example, GM2 is a ganglioside with one sialic acid residue that was the second GM to be identified. Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Ganglioside GD1b Ab.IgM:PrThr:Pt:Ser:Ord:IA
Long Common Name: Ganglioside GD1b IgM Ab [Presence] in Serum by Immunoassay
Short Name: GD1b Gangl IgM Ser Ql IA
Display Name: Ganglioside GD1b IgM IA Ql (S)
Consumer Name Alpha Get Info: Ganglioside GD1b IgM antibody, Blood

Part Model Get Info

Component
Ganglioside GD1b Ab.IgM
LP38224-9
- Analyte
  Ganglioside GD1b Ab.IgM
  LP38224-9
  - Component Numerator
    Ganglioside GD1b Ab.IgM
    LP38224-9
    - Component Numerator Core
      Ganglioside GD1b
      LP14394-8
    - Component Numerator Core Suffix
      Ab.IgM
      LP32403-5
  - Component Denominator
    NULL
    - Component Denominator Core
      NULL
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
PrThr
LP217195-9
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Ser
LP7567-3
- System Core
  Ser
  LP7567-3
- Super System
  NULL
Scale
Ord
LP7751-3
Method
IA
LP217197-5

Example Answer List: LL360-9

Source: Regenstrief Institute

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6

Basic Attributes

Class: SERO
Type: Laboratory
First Released: Version 2.68
Last Updated: Version 2.68 (ADD)
Order vs. Observation: Both

Member of these Panels

LOINC	Long Common Name
82455-7	Ganglioside Ab panel - Serum

Member of these Groups Get Info

LOINC Group	Group Name
LG17197-1	Ganglioside GD1b Ab.IgM\|PrThr\|Pt\|ANYBldSerPl

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Gangliosid GD1b IgM:Přítomnost nebo práh:Časový bod:Sérum:Ordinální:Imunoanalýza
el-GR	Greek (Greece)	Γαγγλιοσίδη GD1b Αντισώματα IgM:PrThr:Pt:Ορός:Ord:IA Synonyms: IA Ord PrThr Pt SERO Ανοσοσφαιρίνη M Αντίσωμα Αντισώματα IgM Γαγγλιοσίδη Γαγγλιοσίδη GD1b Ορός
es-ES	Spanish (Spain)	Gangliosido GD1b IgM:PrThr:Punto temporal:Suero:Ord:IA
es-MX	Spanish (Mexico)	Gangliósido GD1b Ab.IgM:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunoensayo
et-EE	Estonian (Estonia)	Gangliosiid GD1b antikehad.IgM:PrThr:Pt:S:Ord:IA Synonyms: Immuunglobuliin M Järgarvuline Juhuslik Seerum
fr-FR	French (France)	Ganglioside GD1b Ac IgM:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunoanalyse
fr-CA	French (Canada)	Ganglioside GD1b, IgM:Présence-Seuil:Temps ponctuel:Sérum:Ordinal:IA
fr-BE	French (Belgium)	Ganglioside GD1b Anticorps. IgM:PrThr:Temps ponctuel:Sérum:Ordinal:IA Synonyms: Anticorps
it-IT	Italian (Italy)	Ganglioside GD1b Ab.IgM:PrThr:Pt:Siero:Ord:IA Synonyms: Anticorpi IgM anticorpo Immunoassay Presenza o Soglia Punto nel tempo (episodio) Siero Sierologia (anticorpi e la maggior parte degli ant
nl-NL	Dutch (Netherlands)	ganglioside GD1b As.IgM:aanwezigheid:moment:serum:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Gangliozyd GD1b Ab.IgM:granica wykrywalności:punkt w czasie:surowica:uporządkowany:metoda immunologiczna Synonyms: IgM Przeciwciała do gangliozydu GD1a Przeciwciała IgM do gangliozydu GD1b
ru-RU	Russian (Russian Federation)	Ганглиозид GD1b Ат.IgM:PrThr:ТчкВрм:Сыв:Пор:IA Synonyms: Антитело Порядковый Сыворотка Точка во времени;Момент
tr-TR	Turkish (Turkey)	Gangliozid GD1b Ab.IgM:MevcEşik:Zmlı:Ser:Srl:İA Synonyms: Ak Ak.IgM İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	神经节苷脂 GD1b 抗体.IgM:存在情况或阈值:时间点:血清:序数型:免疫测定法 Synonyms: Ab.IgM;IgM;抗体 IgM Ab;自身抗体 GD1b;神经节糖苷 GD1b 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 M 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）时刻;随机;随意;瞬间神经节糖苷神经节苷脂 GD1b Ab 神经节苷脂 GD1b Ab.IgM 神经节苷脂 GD1b IgM 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

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LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.