Version 2.80

Term Description

This tests detects 14q32 rearrangements by fluorescence in situ hybridization (FISH) in patients with multiple myeloma, a white blood cell cancer that affects plasma cells. Four common 14q32 translocations involving the IGH gene include CCND1/t(11;14), FGFR3/t(4;14), MAF/t(14;16) and MAFB/t(14;20).

Part Descriptions

LP418221-0   Chromosome region 14q32 rearrangements
Translocations of the immunoglobulin heavy chain (IgH) gene at 14q32 are routinely present in patients with B lymphoid malignancies and is one of the most common mutations in patients with multiple myeloma (MM). The t(14;20)(q32;q12) translocation may cause the deregulation of existing oncogenes or produce new hybrid genes with altered characteristics. The t(14;20) translocation is detected in very early stages of disease, indicating it may play a role in instigating its development. IgH translocations increase as the disease progresses. The t(14q32) translocation is present in 74% of patients with MM and in 85% of patients with plasma cell leukemia. PMID: 15257707 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , FISH

Fully-Specified Name

Component
Chromosome region 14q32 rearrangements
Property
Find
Time
Pt
System
Bone mar
Scale
Doc
Method
FISH

Additional Names

Long Common Name
Chromosome region 14q32 rearrangements in Bone marrow by FISH
Short Name
Chr 14q32 Rearr Mar FISH
Display Name
14q32 rearrangements FISH Doc (BM)
Consumer Name Alpha Get Info
14q32 rearrangements, Bone marrow

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.68
Last Updated
Version 2.68 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Αναδιατάξεις χρωμοσωμικής περιοχής 14q32:Εύρεση:Pt:Μυελός των οστών:Doc:Φθορίζουσα υβριδοποίηση in situ
Synonyms: Αναδιατάξεις χρωμοσωμικής περιοχής 14q32 Εύρεση Περιοχή Χρωμόσωμα Χρωμοσωμική περιοχή
es-ES Spanish (Spain) Reordenamientos de la región cromosómica 14q32:Hallazgo:Punto temporal:Médula ósea:Doc:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Reordenamientos de la región cromosómica 14q32:Hallazgo:Punto temporal:Médula ósea:Documento:Hibridación fluorescente in situ (FISH)
fr-FR French (France) Chromosome région 14q32 réarrangement:Recherche:Ponctuel:Moelle osseuse:Document:FISH
it-IT Italian (Italy) Regione cromosomica14q32, riarrangiamenti:Osservazione:Pt:Mid oss:Doc:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Midollo osseo Osservazione Patologia molecolare Punto nel tempo (episodio) Riarrangiamento genico
nl-NL Dutch (Netherlands) chromosomale recombinatie van regio 14q32:bevinding:moment:beenmerg:document:FISH
pl-PL Polish (Poland) Rearanżacje w regionie chromosomowym 14q32:wynik:punkt w czasie:szpik kostny:dokument:fluorescencyjna hybrydyzacja in situ (FISH)
zh-CN Chinese (China) 染色体区域 14q32 重排:发现:时间点:骨髓:文档型:FISH
Synonyms: Fluorescent in situ hybridization;荧光原位杂交 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 区;地区;局部 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 染色体二体型+染色体三体型 染色体区域（染色体部位、染色体区、染色体区带、染色体部） 14q32 重排 染色体部位;染色体区;染色体区带;染色体部;染色体区域（染色体部位、染色体区、染色体区带、染色体部） 骨骼;骨头 髓

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CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=95071-7