95527-8

Cytomegalovirus IgG Ab [Presence] in Saliva (oral fluid) by Immunoassay

Active

Term Description

Buccal swab sampling is a noninvasive alternative to determining a patient's cytomegalovirus (CMV) IgG serostatus for non-diagnostic purposes, such as haematopoietic stem cell transplantation donor screening. PMID: 32052845
Source: Regenstrief LOINC

Part Descriptions

LP14255-1 Cytomegalovirus
Cytomegalovirus is a member of the family Herpesviridae and also known as Human Herpesvirus-5 (HHV-5). It contains a linear double-stranded DNA encased in an icosahedral capsid that is surrounded by a viral envelope. It replicates slowly and may take weeks for the infection to become visible microscopically. Its life cycle includes a lytic and a latent phase. During the lytic phase the cytoskeleton of the infected cell is disrupted and becomes very large. The enlarged cell eludes detection by natural killer (NK) cells by encoding UL16. UL16 is a protein that binds to the ligand NDG2D which is a surface receptor on NK cells and, when blocked, prevents the CMV infected cell from apoptotic signaling to NK cells to destroy it.[https://pedclerk.bsd.uchicago.edu/page/cytomegalovirus-cmv] In the US one in three children are infected by CMV by the age of five and over half of adults are infected by age 40. Infection with CMV is mostly asymptomatic. Symptoms when present include fever, sore throat, fatigue, swollen glands. CMV can occasionally lead to mononucleosis or hepatitis. Immunocompromised patients experience much more acute symptoms that can affect the eyes, lungs, liver, esophagus, stomach, and intestines. For babies born with CMV, involvement with the brain, spleen, lung, liver can occur. In addition, there may be growth problems and hearing loss which is the most common symptom in congenital CMV infection. CMV is transmitted in urine, saliva, blood, tears, semen and breast milk by direct contact. Normally no treatment is necessary, but for severe cases medication is available.[https://www.cdc.gov/cmv/overview.html] Source: Regenstrief LOINC

LP7565-7 Saliva
Saliva is produced primarily by the parotid, submaxillary, and sublingual glands. It is secreted at the rate of 0-3 milliliters per minute which is affected by various factors including anxiety, hydration and hunger. Oral fluid is broadly used to test for drugs of abuse in employment and forensic settings, and is especially useful since it is difficult to adulterate, is quick and is non-invasive. Oral fluid is used to test a variety of analytes, including to test alcohol, HIV and other antibodies, therapeutic drugs and steroids, but its primary use is to test for drugs of abuse including amphetamines, cocaine and metabolites, opioids, methadone, cannabis and heroin. PMID: 17268583 Source: Regenstrief LOINC

Fully-Specified Name

Component: Cytomegalovirus Ab.IgG
Property: PrThr
Time: Pt
System: Saliva
Scale: Ord
Method: IA

Additional Names

Short Name: CMV IgG Sal Ql IA
Display Name: CMV IgG IA Ql (Sal)
Consumer Name Alpha Get Info: Cytomegalovirus (CMV) IgG antibody, Saliva

Example Answer List: LL2009-0

Source: ARUP Laboratories

Answer	Code	Score	Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value)			LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value)			LA6577-6
EquivocalCopyright http://snomed.info/sct ID:42425007 Equivocal (qualifier value)			LA11885-3

Basic Attributes

Class: MICRO
Type: Laboratory
First Released: Version 2.69
Last Updated: Version 2.69
Order vs. Observation: Both

Language Variants Get Info

Tag	Language	Translation
de-DE	German (Germany)	Cytomegalie-Virus Ak.IgG:Nachweis oder Schwellenwert:Zeitpunkt:Speichel:Ordinal:Immunoassay Synonyms: CMV
es-MX	Spanish (Mexico)	Citomegalovirus Ab.IgG:Presencia o umbral:Punto temporal:Saliva:Ordinal:Inmunoensayo
es-ES	Spanish (Spain)	Citomegalovirus IgG:PrThr:Punto temporal:Saliva:Ord:IA
et-EE	Estonian (Estonia)	Tsütomegaloviirus antikehad.IgG:PrThr:Pt:Sal:Ord:IA Synonyms: Immuunglobuliin G Järgarvuline Juhuslik Sülg
fr-FR	French (France)	Cytomégalovirus Ac IgG:Présence/Seuil:Ponctuel:Salive:Qualitatif:Immunoanalyse
fr-BE	French (Belgium)	Cytomégalovirus Anticorps. IgG:PrThr:Temps ponctuel:Salivaire:Ordinal:IA Synonyms: Anticorps CMV
fr-CA	French (Canada)	Cytomégalovirus , IgG:Présence-Seuil:Temps ponctuel:Salivaire:Ordinal:IA
it-IT	Italian (Italy)	Citomegalovirus Ab.IgG:PrThr:Pt:Saliva:Ord:IA Synonyms: anticorpi IgG anticorpo Immunoassay Microbiologia Presenza o Soglia Punto nel tempo (episodio)
nl-NL	Dutch (Netherlands)	Cytomegalovirus As.IgG:aanwezigheid:moment:speeksel:ordinaal:immunoassay Synonyms: antistof; antilichaam IA
pl-PL	Polish (Poland)	Wirus cytomegalii Ab.IgG:granica wykrywalności:punkt w czasie:ślina:półilościowy:metoda immunologiczna Synonyms: Cytomegalowirus IgG Przecwciała do cytomegalowirusa Przecwciała IgG do cytomegalowirusa
ru-RU	Russian (Russian Federation)	Цитомегаловирус Ат.IgG:PrThr:ТчкВрм:Слюна:Пор:IA Synonyms: Антитело Порядковый Точка во времени;Момент
tr-TR	Turkish (Turkey)	Cytomegalovirus Ab.IgG:MevcEşik:Zmlı:Tükürük:Srl:İA Synonyms: Ak Ak.IgG İmmünölçüm, immünoassay Mevcut
zh-CN	Chinese (China)	巨细胞病毒抗体.IgG:存在情况或阈值:时间点:唾液:序数型:免疫测定法 Synonyms: Ab.IgG;IgG;抗体 IgG Ab;自身抗体 CMV Ab CMV Ab.IgG CMV IgG CMV 抗体 CMV 抗体.IgG CMV;涎腺病毒;细胞巨化病毒;细胞肥大病毒依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验免疫球蛋白 G 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值）巨细胞病毒 Ab 巨细胞病毒 Ab.IgG 巨细胞病毒 IgG 微生物学;微生物学试验;微生物学试验（培养、DNA、抗原及抗体）时刻;随机;随意;瞬间津;津液;涎

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