95654-0
Eastern equine encephalitis virus neutralizing antibody [Titer] in Specimen by Neutralization test
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Part Descriptions
LP14238-7 Eastern equine encephalitis virus
Eastern equine encephalitis virus (EEEV), commonly called sleeping sickness or Triple E, is a zoonotic alphavirus and arbovirus present in North, Central and South America and the Caribbean. EEEV was first recognised in Massachusetts, USA in 1831 when 75 horses died of encephalitic illness. Epizootics in horses have continued to occur regularly in USA. The causal agent, EEEV, was first isolated from infected horse brains in 1933. In 1938, the first confirmed human cases were identified when thirty children died of encephalitis in northeastern USA. These cases coincided with outbreaks in horses in the same regions. The fatality rate in humans infected with EEEV is 35%. EEEV is capable of infecting a wide range of animals including mammals, birds, reptiles and amphibians, but not all animals develop high enough levels of EEEV to be contagious to humans. The virus is maintained in birds primarily through Culiseta melanura mosquitoes and transmission to other species occurs via mosquitoes.
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Source: Wikipedia, Eastern equine encephalitis virus (Wikipedia)
LP14238-7 Eastern equine encephalitis virus
Eastern equine encephalitis is an encephalitogenic arbovirus common in North America and transmitted to humans via an arthropod vector. Central nervous system infection may present as aseptic meningitis, encephalitis, or meningoencephalitis. Information from ARUP Laboratories and Jacobs and DeMott Laboratory Test Handbook, 5th edition, DS Jacobs, WR DeMott and DK Oxley, 2001.
Source: Regenstrief Institute
LP207365-0 Ab.Neut
Neutralizing antibodies are antibodies that interfere with the interaction between the virus and its host cell receptor, therefore preventing infectivity. Neutralizing antibodies can be detected using a traditional VNT or other methods such as pseudovirus VNT and surrogate VNT. VNT and pseudovirus VNT use live virus (the actual virus or a recombinant virus that incorporates the viral antigen of interest, respectively) and cell culture to assess the virus-host interaction and whether neutralizing antibodies are present that block that interaction. Surrogate VNT (sVNT) does not use live virus but rather uses purified viral antigen and host cell receptor protein to mimic the same interaction. The sVNT method is currently (2021) represented in LOINC as IA, because it is an immunoassay-based method.
Source: Regenstrief LOINC
LP6416-4 Neut
In LOINC, the Method "Neut" represents the virus neutralization test (VNT), also called conventional VNT, which is a specific laboratory method that is used primarily for identifying whether neutralizing antibodies for the virus of interest are present in the patient sample. The VNT involves incubating patient serum with the virus of interest, and then inoculating onto cell culture. If neutralizing antibodies are present and the virus is neutralized, the cells will not be infected. If neutralizing antibodies are not present, the virus will infect the cells in the cell culture. PMID: 32170698 This method can also be used to identify specific virus serotypes or strains, by performing separate tests in which serum is incubated with each of the specific virus serotypes or strains of interest. PMID: 169804
Source: Regenstrief LOINC
Fully-Specified Name
- Component
- Eastern equine encephalitis virus Ab.Neut
- Property
- Titr
- Time
- Pt
- System
- XXX
- Scale
- SemiQn
- Method
- Neut
Additional Names
- Short Name
- EEEV NAb Titr Spec Nt
- Display Name
- EEEV neut ab Neut test (Specimen) [Titer]
- Consumer Name Alpha Get Info
- Eastern equine encephalitis virus neutralizing antibody, Specimen
Basic Attributes
- Class
- MICRO
- Type
- Laboratory
- First Released
- Version 2.69
- Last Updated
- Version 2.75
- Change Reason
- Release 2.72: COMPONENT: Updated "Ab" to "Ab.Neut" since this test is detecting neutralizing antibodies.;
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG32751-6 | Eastern equine encephalitis virus |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Virus de la Encefalitis Equina del este Anticuerpos antineutrófilos: Synonyms: Semicuantitativo |
| es-MX | Spanish (Mexico) | Virus de la encefalitis equina del este Ab: |
| fr-FR | French (France) | Encéphalite équine de l'est virus Ac: |
| fr-CA | French (Canada) | Virus de l'encéphalite équine de l'Est Ac.neut: |
| it-IT | Italian (Italy) | Encefalite equina orientale virus Ab.Neut: Synonyms: anticorpo Microbiologia Punto nel tempo (episodio) Test di neutralizzazione Titolo Virus dell''encefalite equina orientale |
| nl-NL | Dutch (Netherlands) | Oosters equien encefalitisvirus As.neutraliserend: Synonyms: antistof; |
| pl-PL | Polish (Poland) | Wirus wschodniego końskiego zapalenia mózgu Ab.Neutralizujące: Synonyms: Przeciwciała do wirusa wschodniego końskiego zapalenia mózgu Przeciwciała neutralizujące do wirusa wschodniego końskiego zapalenia mózgu Wirus wschodniego końskiego zapalenia mózgu |
| zh-CN | Chinese (China) | 东方马脑炎病毒 抗体.中和: Synonyms: Ab; |
Example Units
| Unit | Source |
|---|---|
| {titer} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=95654-0
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