Version 2.78

Term Description

Daratumumab is a monoclonal antibody used to treat multiple myeloma, which is, itself, a disease that results in antibody overproduction, shown as M protein band in immunoelectrophoresis. Daratumumab, the treatment, can show up as part of the M spike and interfere with the assay for the M-protein in multiple myeloma. An antibody against Daratumumab can be added to the assay, which shifts the Daratumumab band, allowing the Daratumumab band to be distinguished from the M-protein band and reported separately.
Source: Regenstrief LOINC

Part Descriptions

LP420302-4   Daratumumab
Daratumumab is a biologic drug used to treat multiple myeloma. It is a IgG1k human monoclonal antibody directed against CD38, a molecule present on myeloma cells. By binding to CD38, it inhibits the growth of CD38 expressing tumor cells and causes cell death by immune mediated tumor cell lysis PMID: 29915586. Source: Regenstrief LOINC

LP6336-4   Immunofixation
Plasma or concentrated urine is deposited on a gel. With an electrical current the proteins are sorted in function of their size, after which antigens for each targeted type of immunoglobulin are deposited on the gel. Thus more or less narrow bands appear on the gel, marking the location of the various immunoglobulines.
Immunofixation tends to replace protein electrophoresis because:

• it is faster (results within three hours);
• it is somewhat more sensitive. Immunofixation may reveal an immunoglobulin missed out by protein electrophoresis, especially at low concentrations (less than 1 gram/litre);
• it can be partially automated and can be used in more laboratories;
• it is more easily read and interpreted.

Immunofixation is however only sensitive to immunoglobulins and is more expensive than protein electrophoresis. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Immunofixation

Fully-Specified Name

Component
Daratumumab
Property
PrThr
Time
Pt
System
Ser
Scale
Ord
Method
Immunofixation

Additional Names

Long Common Name
Daratumumab [Presence] in Serum by Immunofixation
Short Name
Daratumumab Ser Ql IFE
Display Name
Daratumumab Immunofixation Ql (S)
Consumer Name Alpha Get Info
Daratumumab, Blood

Example Answer List: LL744-4

Source: Regenstrief Institute
Answer Code Score Answer ID
Detected LA11882-0
Not detected LA11883-8

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
de-AT German (Austria) Synonyms: Daratumumab IF
es-ES Spanish (Spain) Daratumumab:PrThr:Punto temporal:Suero:Ord:Inmunofijación
es-MX Spanish (Mexico) Daratumumab:Presencia o umbral:Punto temporal:Suero:Ordinal:Inmunofijación
fr-FR French (France) Daratumumab:Présence/Seuil:Ponctuel:Sérum:Qualitatif:Immunofixation
it-IT Italian (Italy) Daratumumab:PrThr:Pt:Siero:Ord:Immunofissazione
Synonyms: Chimica Presenza o Soglia Punto nel tempo (episodio) Siero
nl-NL Dutch (Netherlands) daratumumab:aanwezigheid:moment:serum:ordinaal:immunofixatie
zh-CN Chinese (China) 达雷妥尤单抗:存在情况或阈值:时间点:血清:序数型:免疫固定电泳分析法
Synonyms: IFE;Ifix;免疫固定法;免疫固定电泳（Immunofixation electrophoresis，IFE）;免疫固定电泳法 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 达雷木单抗;人源化抗CD38 IgG1单克隆抗体

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CodeSystem lookup
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