Version 2.80

Part Descriptions

LP420673-8   ABL1 & ABL2 & PDGFRB gene rearrangements
Rearrangements or fusions involving ABL-class genes, including ABL1, ABL2 and PDGFRB, are associated with BCR-ABL1-like B-lymphoblastic leukemia/lymphoma (BCR-ABL1-like B-ALL), also known as Philadelphia-like (Ph-like) ALL. Ph-like ALL is characterized as a neoplasm of B lymphoblasts having gene expression similar to BCR-ABL1+ B-ALL cases but lacking the BCR-ABL1 translocation. Several methods are used to diagnose Ph-like ALL, including gene expression profiling (the "gold standard"), conventional karyotyping, fluorescence in situ hybridization (FISH), reverse-transcription polymerase chain reaction (RT-PCR), and various sequencing techniques. For positive FISH studies, additional fusion probe or RT-PCR testing is needed to identify translocation partners. Patients with Ph-like ALL have a poor prognosis but respond well to targeted therapy when the genetic cause is identified. Treatment options include tyrosine kinase inhibitors (TKIs) and chemotherapy. PMID: 29696694 PMID: 25682595 Source: Regenstrief LOINC

LP62864-1   FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , FISH

Fully-Specified Name

Component
ABL1 & ABL2 & PDGFRB gene rearrangements
Property
Find
Time
Pt
System
Bld/Tiss
Scale
Doc
Method
FISH

Additional Names

Long Common Name
ABL1 and ABL2 and PDGFRB gene rearrangements in Blood or Tissue by FISH
Short Name
ABL1 + ABL2 + PDGFRB rearr Bld/T FISH
Display Name
ABL1 and ABL2 and PDGFRB gene rearrangements FISH Doc (Bld/Tiss)
Consumer Name Alpha Get Info
ABL1 and ABL2 and PDGFRB gene rearrangements, Blood or tissue specimen

Basic Attributes

Class
MOLPATH.REARRANGE
Type
Laboratory
First Released
Version 2.69
Last Updated
Version 2.69 (ADD)
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
el-GR Greek (Greece) Γονιδιακές αναδιατάξεις ABL1 & ABL2 & PDGFRB:Εύρεση:Pt:Αίμα/Ιστός:Doc:Φθορίζουσα υβριδοποίηση in situ
Synonyms: Γονιδιακές αναδιατάξεις ABL1 & ABL2 & PDGFRB Γονιδιακές αναδιατάξεις PDGFRB Γονίδιο Εύρεση
es-ES Spanish (Spain) Reordenamientos de los genes ABL1 y ABL2 y PDGFRB:Hallazgo:Punto temporal:Sangre o tejido:Doc:Hibridación in situ fluoresente (FISH)
es-MX Spanish (Mexico) Reordenamientos de genes ABL1, ABL2 y PDGFRB:Hallazgo:Punto temporal:Sangre o tejido:Documento:Hibridación fluorescente in situ (FISH)
fr-FR French (France) ABL1 et ABL2 et PDGFRB gène réarrangements:Recherche:Ponctuel:Sang/Tissu:Document:FISH
it-IT Italian (Italy) ABL1 & ABL2 & PDGFRB, riarrangiamenti dei geni:Osservazione:Pt:Sangue/Tess:Doc:FISH
Synonyms: Ibridazione in situ fluorescente (FISH) Osservazione Patologia molecolare Punto nel tempo (episodio) Riarrangiamenti dei geni ABL1 e ABL2 e PDGFRB Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & Strisci
nl-NL Dutch (Netherlands) ABL1 & ALB2 & PDGFRB genherschikking:bevinding:moment:bloed of weefsel:document:FISH
Synonyms: ABL1 & ALB2 & PDGFRB gentranslocaties PDGFRB-gentranslocaties
zh-CN Chinese (China) ABL1 & ABL2 & PDGFRB 基因重排:发现:时间点:全血/组织:文档型:FISH
Synonyms: ABL ABL1 & ABL2 & PDGFRB 基因重排（重组） Beta 血小板源性生长因子受体前体 Beta 血小板源性生长因子受体前体（Beta platelet-derived growth factor receptor precursor，PDGFRB） CD140B 基因 Fluorescent in situ hybridization;荧光原位杂交 JTK12 JTK7 p150 PDGFbetaR PDGFR PDGFR1 PDGFRB 基因重排（重组） PDGF-R-BETA PDGF-R-β PDGFβR v-abl Abelson murine leukemia viral oncogene homolog 1 v-abl Abelson 小鼠白血病病毒癌基因同源体 1 v-abl Abelson 小鼠白血病病毒肿瘤基因同源体 1 v-abl Abelson 小鼠白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科动物白血病病毒致癌基因同源体 1 v-abl Abelson 鼠科白血病病毒致癌基因同源体 1 β血小板源性生长因子受体前体 临床文档型;临床文档;文档;文书;医疗文书;临床医疗文书 全血或组织;血液/组织;血液或组织 分子病理学.基因重排;分子病理学.重排;分子病理学试验.基因重排;分子病理学试验.重排;分子病理学试验类.重排;基因重排;重排 分子病理学;分子病理学试验 发现是一个原子型临床观察指标，并不是作为印象的概括陈述。体格检查、病史、系统检查及其他此类观察指标的属性均为发现。它们的标尺对于编码型发现可能是名义型，而对于叙述型文本之中所报告的发现，则可能是叙述型。;发现物;所见;结果;结论 时刻;随机;随意;瞬间 未作说明的组织;组织;组织 & 涂片 血;血液 遗传基因;遗传因子;吉恩;生物基因

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=96494-0