96495-7
ABL2 gene rearrangements in Blood or Tissue by FISH
Active
Part Descriptions
LP420672-0 ABL2 gene rearrangements
Rearrangements or fusions involving ABL-class genes, including ABL1, ABL2 and PDGFRB, are associated with BCR-ABL1-like B-lymphoblastic leukemia/lymphoma (BCR-ABL1-like B-ALL), also known as Philadelphia-like (Ph-like) ALL. Ph-like ALL is characterized as a neoplasm of B lymphoblasts having gene expression similar to BCR-ABL1+ B-ALL cases but lacking the BCR-ABL1 translocation. Several methods are used to diagnose Ph-like ALL, including gene expression profiling (the "gold standard"), conventional karyotyping, fluorescence in situ hybridization (FISH), reverse-transcription polymerase chain reaction (RT-PCR), and various sequencing techniques. For positive FISH studies, additional fusion probe or RT-PCR testing is needed to identify translocation partners. Patients with Ph-like ALL have a poor prognosis but respond well to targeted therapy when the genetic cause is identified. Treatment options include tyrosine kinase inhibitors (TKIs) and chemotherapy. PMID: 29696694 PMID: 25682595
Source: Regenstrief LOINC
LP420672-0 ABL2 gene rearrangements
The ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) gene is located on chromosome 1 and encodes a member of the Abelson family of nonreceptor tyrosine protein kinases.[NCBI Gene ID: 27] ALB2 is an important factor in cytoskeletal rearrangements and involved in cell growth and survival. Genetic rearrangements involving the ABL2 gene are associated with leukemias, including Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). PMID: 31189154
Source: LOINC
LP62864-1 FISH
FISH (fluorescence in situ hybridization) is a cytogenetic technique used to detect and localize the presence or absence of specific DNA sequences on chromosomes. FISH uses fluorescent probes that bind to only those parts of the chromosome with which they show a high degree of sequence similarity. Fluorescence microscopy can be used to find out where the fluorescent probe bound to the chromosomes. FISH is often used for finding specific features in DNA for use in genetic counseling, medicine, and species identification. FISH can also be used to detect and localize specific mRNAs within tissue samples. In this context, it can help define the spatial-temporal patterns of gene expression within cells and tissues.
Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details.
Source: Wikipedia
, FISH
Fully-Specified Name
- Component
- ABL2 gene rearrangements
- Property
- Find
- Time
- Pt
- System
- Bld/Tiss
- Scale
- Doc
- Method
- FISH
Additional Names
- Long Common Name
- ABL2 gene rearrangements in Blood or Tissue by FISH
- Short Name
- ABL2 rearrange Bld/T FISH
- Display Name
- ABL2 gene rearrangements FISH Doc (Bld/Tiss)
- Consumer Name Alpha Get Info
- ABL2 gene rearrangements, Blood or tissue specimen
Basic Attributes
- Class
- MOLPATH.REARRANGE
- Type
- Laboratory
- First Released
- Version 2.69
- Last Updated
- Version 2.69 (ADD)
- Order vs. Observation
- Both
Language Variants Get Info
Tag | Language | Translation |
---|---|---|
el-GR | Greek (Greece) | Γονιδιακές αναδιατάξεις ABL2: Synonyms: Γονιδιακές αναδιατάξεις ABL2 Γονίδιο Εύρεση |
es-ES | Spanish (Spain) | Reordenamientos del gen ABL2: |
es-MX | Spanish (Mexico) | Reordenamientos del gen ABL2: |
fr-FR | French (France) | ABL2 gène réarrangements: |
it-IT | Italian (Italy) | ABL2, riarrangiamenti del gene: Synonyms: Ibridazione in situ fluorescente (FISH) Osservazione Patologia molecolare Punto nel tempo (episodio) Riarrangiamento genico Sangue Sangue o Tessuto Tessuto & |
nl-NL | Dutch (Netherlands) | ABL2 genherschikking: Synonyms: ABL2 gentranslocaties |
zh-CN | Chinese (China) | ABL2 基因重排: Synonyms: ABL2 基因重排(重组) Fluorescent in situ hybridization; |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=96495-7
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://