LP420672-0
ABL2 gene rearrangements
Active
Descriptions
Rearrangements or fusions involving ABL-class genes, including ABL1, ABL2 and PDGFRB, are associated with BCR-ABL1-like B-lymphoblastic leukemia/lymphoma (BCR-ABL1-like B-ALL), also known as Philadelphia-like (Ph-like) ALL. Ph-like ALL is characterized as a neoplasm of B lymphoblasts having gene expression similar to BCR-ABL1+ B-ALL cases but lacking the BCR-ABL1 translocation. Several methods are used to diagnose Ph-like ALL, including gene expression profiling (the "gold standard"), conventional karyotyping, fluorescence in situ hybridization (FISH), reverse-transcription polymerase chain reaction (RT-PCR), and various sequencing techniques. For positive FISH studies, additional fusion probe or RT-PCR testing is needed to identify translocation partners. Patients with Ph-like ALL have a poor prognosis but respond well to targeted therapy when the genetic cause is identified. Treatment options include tyrosine kinase inhibitors (TKIs) and chemotherapy. PMID: 29696694 PMID: 25682595 Source: Regenstrief LOINC
The ABL2 (ABL proto-oncogene 2, non-receptor tyrosine kinase) gene is located on chromosome 1 and encodes a member of the Abelson family of nonreceptor tyrosine protein kinases.[NCBI Gene ID: 27] ALB2 is an important factor in cytoskeletal rearrangements and involved in cell growth and survival. Genetic rearrangements involving the ABL2 gene are associated with leukemias, including Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL). PMID: 31189154 Source: LOINC
Basic Part Properties
- Part Name
- ABL2 gene rearrangements
- Part Display Name
- ABL2 gene rearrangements
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2020-10-24
- Construct for LOINC Short Name
- ABL2 rearrange
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| es-ES | Spanish (Spain) | Reordenamientos del gen ABL2 |
| zh-CN | Chinese (China) | ABL2 基因重排 Synonyms: ABL2 基因重排（重组） |
| it-IT | Italian (Italy) | ABL2, riarrangiamenti del gene |
| nl-NL | Dutch (Netherlands) | ABL2 genherschikking Synonyms: ABL2 gentranslocaties |
| el-GR | Greek (Greece) | Γονιδιακές αναδιατάξεις ABL2 Synonyms: Γονιδιακές αναδιατάξεις ABL2 |
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