97599-5

CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Lower respiratory specimen by Flow cytometry (FC)

Active

Part Descriptions

LP100021-7 Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7 Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7 Cells.CD3+CD4+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP14443-3 CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2 CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LOINC Names Get Info

Fully-Specified Name: Cells.CD3+CD4+/Cells.CD3+CD8+:NRto:Pt:Respiratory system specimen.lower:Qn:Flow cytometry
Long Common Name: CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Lower respiratory specimen by Flow cytometry (FC)
Short Name: CD3+CD4+ Cells/CD3+CD8+ Cells L resp FC
Display Name: CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells FC (Lower resp) [# ratio]
Consumer Name Alpha Get Info: CD3+CD4+ (T4 Helper) Cells/CD3+CD8+ (T8 Suppressor Cells) Cells, Lower respiratory

Part Model Get Info

Component
Cells.CD3+CD4+/Cells.CD3+CD8+
LP285424-0
- Analyte
  Cells.CD3+CD4+/Cells.CD3+CD8+
  LP285424-0
  - Component Numerator
    Cells.CD3+CD4+
    LP14441-7
    - Component Numerator Core
      Cells.CD3+CD4+
      LP14441-7
    - Component Numerator Core Suffix
      NULL
  - Component Denominator
    Cells.CD3+CD8+
    LP100021-7
    - Component Denominator Core
      Cells.CD3+CD8+
      LP100021-7
    - Component Denominator Core Suffix
      NULL
- Challenge
  NULL
- Adjustment
  NULL
- Count
  NULL
Property
NRto
LP6840-5
Time
Pt
LP6960-1
- Time Core
  Pt
  LP6960-1
- Time Modifier
  NULL
System
Respiratory system specimen.lower
LP438102-8
- System Core
  Respiratory system specimen.lower
  LP438102-8
- Super System
  NULL
Scale
Qn
LP7753-9
Method
Flow cytometry
LP6274-7

Basic Attributes

Class: CELLMARK
Type: Laboratory
First Released: Version 2.70
Last Updated: Version 2.77 (MAJ)
Change Reason: Release 2.77: SYSTEM: Updated to standardize the representation of "Respiratory system specimen" in the System subhierarchy across LOINC;
Order vs. Observation: Observation

Member of these Panels

LOINC	Long Common Name
97593-8	Lymphocyte T-cell and B-cell and Natural killer subsets panel - Lower respiratory specimen by Flow cytometry (FC)

Language Variants Get Info

Tag	Language	Translation
cs-CZ	Czech (Czechia)	Buňky.CD3+CD4+/buňky.CD3+CD8+:Početní poměr:Časový bod:Vzorek dolních cest dýchacích:Kvantitativní:Průtoková cytometrie
el-GR	Greek (Greece)	Κύτταρα.CD3+CD4+/Κύτταρα.CD3+CD8+:NRto:Pt:Δείγμα αναπνευστικού συστήματος.κατώτερο:Qn:Κυτταρομετρία ροής Synonyms: CD3 CD4 CD8 CELLMARK NRto Pt Qn Αναπνευστικό Αναπνευστικό σύστημα Δείγμα Δείγμα αναπνευστικού συστήματος Δείγμα αναπνευστικού συστήματος.κατώτερο Κύτταρα Κύτταρα.CD3 Κύτταρα.CD3+CD4+ Κύτταρα.CD3+CD8+ Κύτταρα.CD3-CD4+ Κυτταρομετρία ροής
es-MX	Spanish (Mexico)	Cells.CD3 + CD4 + / Cells.CD3 + CD8 +:NRto:Punto temporal:Respiratorio.bajo:Cuantitativo:Citometría de flujo
es-ES	Spanish (Spain)	Células CD3+CD4+/Células CD3+CD8+:Relación de número:Punto temporal:Muestra de vías respiratorias inferiores:Qn:Citometria de flujo (FC) Synonyms: Cuantitativo Muestra del tracto respiratorio Muestra respiratoria Tracto respiratorio
fr-FR	French (France)	CD3+CD4+/CD3+CD8+:Nombre/Nombre:Ponctuel:Échantillon du système respiratoire inférieur:Numérique:Cytométrie de flux
it-IT	Italian (Italy)	Cellule.CD3+CD4+/Cellule.CD3+CD8+:NRto:Pt:Campione da Sistema Respiratorio.inferiore:Qn:Citometria a flusso Synonyms: Campione da Apparato Respiratorio Campione da apparato respiratorio inferiore Cellule CD3 Cellule CD3+CD4+ Cellule CD3+CD8+ Cellule CD3+CD8+ (cellule soppressore T8) Cellule CD3-CD4+ Citometria a flusso (FC) Modelli di superficie cellulare Punto nel tempo (episodio) Rapporto numerico
nl-NL	Dutch (Netherlands)	cellen.CD3+CD4+/cellen.CD3+CD8+:aantalsverhouding:moment:onderste luchtwegen:kwantitatief:flowcytometrie Synonyms: onderste ademhalingsstelsel; systema respiratorium inferior systema respiratorium; ademhalingsstelsel
pl-PL	Polish (Poland)	Komórki.CD3+CD4+/komórki CD3+ CD8+:współczynnik liczbowy:punkt w czasie:próbka z układu oddechowego.dolna część:ilościowy:cytometria przepływowa (FC) Synonyms: CD4 CD8 Komórki CD3+CD4+ Komórki CD3+CD8+ próbka z dolnych dróg układu oddechowego
zh-CN	Chinese (China)	细胞.CD3+CD4+/细胞.CD3+CD8+:计数型比率:时间点:呼吸系统标本.下:定量型:流式细胞测量术 Synonyms: CD3+CD4+细胞 CD3+CD8+细胞 CD3-CD4+细胞 CD3细胞 L3T4 Leu2 Leu-2 Leu3 Leu-3 Leu4;Leu-4;T3 T4 T-4 T8 T-8 Tsuppressor W3/25 下下的下部低级低级的供检查用的材料;待检物;待试验物;样品;样本;试料;试样动态发现于抑制性 T-细胞/细胞毒性 T-细胞、一些 NK 细胞之上。与一些成熟 T-细胞肿瘤和大颗粒淋巴细胞增多症相关发现于辅助 T-细胞；微弱表达于单核细胞。与相关。一些成熟 T-细胞肿瘤，包括大多数情况下的 T-细胞慢性淋巴细胞白血病/前淋巴细胞白血病、外周 T-细胞淋巴瘤、成人 T-细胞白血病/淋巴瘤以及 Sézary 综合征（T 细胞红皮病）/蕈样肉芽肿（mycosis fungoides）。受检物可用数量表示的;定量性;数值型;数量型;连续数值型标尺同一样本内两种不同实体的数量之比;数量型比;数量型比值;数量型比率;数量或计数型比;数量或计数型比值;计数型比;计数型比值;数量或计数型比率呼吸系统（呼吸道）标本.下;下呼吸系统标本;下呼吸道标本呼吸道标本（样品、样本）;呼吸系统标本（样品、样本）抑制性 T 细胞抑制性 T-细胞时刻;随机;随意;瞬间样品样本流流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计细胞含量;细胞性;细胞性质;细胞构成;细胞类细胞标志物试样诱导 T 细胞诱导性 T 细胞较低较低的辅助 T 细胞辅助诱导 T 细胞辅助诱导物 T 细胞

Example Units

Unit	Source
%	Example UCUM Units

LOINC Terminology Service (API) using HL7^® FHIR^® Get Info

CodeSystem lookup: https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=97599-5

LOINC Copyright

Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://loinc.org/license for the full LOINC copyright and license.