LOINC
Version 2.70

97599-5CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells [# Ratio] in Lower respiratory specimen by Flow cytometry (FC)Active

Part Descriptions

LP14441-7   Cells.CD3+CD4+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

LP14441-7   Cells.CD3+CD4+
HIV infection decreases the number of CD4 T-cells, also called T4 helper cells, the ratio of CD4 to CD8 T-cells and the number of CD8+ T-cells. These counts are ordered frequently to guide decisions about anti-retroviral therapy. Laboratories usually report both percentage and absolute count. When you map CD4 and CD8 markers, be careful! Since at least 1997, CDC has required the detection of both CD3+ and CD4+ to identify T4 helper cells, because the CD3 marker is needed to identify T-cell . So, any tests that report T4 helper cells are really reporting cells that carry BOTH the CD3+ and the CD4+ markers. The measure name may be CD3+ CD4+ cells, CD4+ marker, T4 cells or even just CD4+ (a misnomer). Exactly analogous rules apply to CD8+. Measures that include only CD4 or only CD8 in their name are really measuring CD3+CD4+ cells or CD3+CD8+ cells, respectively and should be reported with the LOINC code that includes both of those markers. The panel named T cell subsets will usually contain both CD3 + CD4 and CD3 + CD8 counts. These names assume that one has already gated to lymphocytes only. Lymphocytes are identified by CD45 markers. So a CD45+CD3+CD4+ is a more complicated way to name CD3+C4+ cells and in the context of looking for CD4 helper T cells they are the same . The same applies to other flow cytometer measures that are looking only at lymphocytes (B-cells, NK cells, etc). Source: Regenstrief Help

LP14443-3   CD4
Found on helper T-cells; weakly expressed on monocytes.
Associated with some mature T-cell neoplasms, including most cases of T-cell CLL/prolymphocytic leukemia, peripheral
T-cell lymphoma, adult T-cell leukemia/lymphoma and Sézary syndrome/mycosis fungoides Source: Regenstrief LOINC

LP17729-2   CD8
Found on T-suppressor/cytotoxic cells and some Natural Killer cells; Associated with some mature T-cell neoplasms; Large granular lymphocytosis Source: Regenstrief LOINC

LP100021-7   Cells.CD3+CD8+
HIV infection decreases the number of CD3+ CD4+ lymphocytes (also called CD4 T cells or T4 helper cells) while increasing (momentarily) the numbers of CD3+CD8+ lymphocytes (called CD8 T lymphocytes or cytotoxic T cells). Thus the ratio of CD4/CD8 lymphocytes is decreased. These counts are used for prognostic purposes and to guide in the retroviral therapy. CDC has emphasized since 1997 that the number of CD3+ lymphocytes is necessary in addition to the number of CD4+ cells to reliably identify the T4 helper cells and the number of CD8+ cells. Laboratory reports that include only CD4 or only CD8 in their nomenclature are most likely really measuring CD3+CD4+ cells and CD3+CD8+ cells, respectively. Source: Regenstrief Help

Fully-Specified Name

Component
Cells.CD3+CD4+/Cells.CD3+CD8+
Property
NRto
Time
Pt
System
Respiratory.lower
Scale
Qn
Method
Flow cytometry

Additional Names

Short Name
CD3+CD4+ Cells/CD3+CD8+ Cells L resp FC
Display Name
CD3+CD4+ (T4 helper) cells/CD3+CD8+ (T8 suppressor cells) cells FC (Lower resp) [# ratio]
Consumer Name Alpha
CD3+CD4+ (T4 Helper) Cells/CD3+CD8+ (T8 Suppressor Cells) Cells, Lower respiratory

Basic Attributes

Class
CELLMARK
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.70
Order vs. Observation
Observation

Member of these Panels

LOINC Long Common Name
97593-8 Lymphocyte T-cell and B-cell and Natural killer subsets panel - Lower respiratory specimen by Flow cytometry (FC)

Language Variants Get Info

zh-CNChinese (China)
细胞.CD3+CD4+/细胞.CD3+CD8+:计数型比率:时间点:呼吸道.下:定量型:流式细胞测量术
nl-NLDutch (Netherlands)
cellen.CD3+CD4+/cellen.CD3+CD8+:aantalsverhouding:moment:onderste luchtwegen:kwantitatief:flowcytometrie
fr-CAFrench (Canada)
Cellules.CD3+CD4+/Cellules.CD3+CD8+:Ratio de numérique:Temps ponctuel:Système respiratoire.inférieur:Quantitatif:Cytométrie de flux
it-ITItalian (Italy)
Cellule.CD3+CD4+/Cellule.CD3+CD8+:NRto:Pt:Sistema respiratorio.inferiore:Qn:Citometria a flusso
es-ESSpanish (Spain)
Células CD3+CD4+/Células CD3+CD8+:Relación de número:Punto temporal:Tracto respiratorio inferior:Qn:Citometria de flujo (FC)
tr-TRTurkish (Turkey)
Hücreler.CD3+CD4+/Hücreler.CD3+CD8+:SayOr:Zmlı:Respiratuvar.alt:Kant:Akış sitometri

Example Units

Unit Source
% Example UCUM Units

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=97599-5