Version 2.78

Term Description

NK cell cytotoxicity is used to evaluate patients with NK cell deficiency and genetic hemophagocytic lymphohistiocytosis and to measure NK cell cytotoxic function in postallogeneic hematopoietic cell transplantation and solid organ transplants.
Source: Regenstrief LOINC

Part Description

LP264987-1   Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. PMID: 14685277 In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. PMID: 1842510 Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. PMID: 11470149 Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells PMID: 23650441 and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

Panel Hierarchy

Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
98030-0 Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC)
Indent33193-4 Viable cells/100 cells in Blood %
Indent90242-9 Natural killer cell cytotoxicity.IL-stimulated 0.9:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90243-7 Natural killer cell cytotoxicity.IL-stimulated 1.88:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90245-2 Natural killer cell cytotoxicity.IL-stimulated 3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90249-4 Natural killer cell cytotoxicity.IL-stimulated 7.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90244-5 Natural killer cell cytotoxicity.IL-stimulated 15:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90241-1 Natural killer cell cytotoxicity.IL-2 stimulated 30:1 effector to target cell ratio/Positive control in Blood mononuclear cells %

Fully-Specified Name

Component
Natural killer cell cytotoxicity.IL-2 stimulated panel
Property
-
Time
Pt
System
Bld MC
Scale
-
Method
Flow cytometry

Additional Names

Short Name
NK cyto IL2 Pnl Bld MC FC
Display Name
NK cytotoxicity.IL-2 stim panel FC (Bld MC)
Consumer Name Alpha Get Info
NK Cytotoxicity.IL-2 Stim panel, Blood

Basic Attributes

Class
PANEL.CELLMARK
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.70
Order vs. Observation
Order
Panel Type
Panel

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Panel de citotoxicidad de células Natural killer estimuladas con IL-2:Propiedades mixtas (sólo paneles):Punto temporal:Celulas Mononucleares sanguíneas:-:Citometria de flujo (FC)
es-MX Spanish (Mexico) Citotoxicidad de células asesinas naturales Panel estimulado con IL-2:-:Punto temporal:Bld MC:-:Citometría de flujo
fr-FR French (France) Cytotoxicité cellules NK stimulées par IL-2 panel:-:Ponctuel:Cellules mononucléées de sang périphérique:-:Cytométrie de flux
it-IT Italian (Italy) Cellula natural killer, citotossicità. rapporto IL-2 stimolato, panel:-:Pt:Cellule mononucleate da sangue intero:-:Citometria a flusso
Synonyms: Citometria a flusso (FC) Modelli di superficie cellulare Panel cellula natural killer, citotossicità. rapporto IL-2 stimolato Punto nel tempo (episodio) Sangue Set di prescrizione per marcatore cellulare
nl-NL Dutch (Netherlands) 'natural killer'-cel cytotoxiciteit.IL-2-gestimuleerd panel:-:moment:mononucleaire cellen in bloed:-:flowcytometrie
Synonyms: NK-cel
zh-CN Chinese (China) 自然杀伤细胞细胞毒性.IL-2 刺激型组套:-:时间点:全血单个核细胞:-:流式细胞测量术
Synonyms: Ⅱ II 全血（血液、血）单个核细胞（单核细胞、MC）;全血标本（样品、样本、试样）单个核细胞 动态 医嘱套餐 医嘱套餐类 医嘱套餐组 医嘱组 医嘱组.细胞标志物;组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目）类.细胞标志物;实验室医嘱组类.细胞标志物;细胞标志物医嘱组;细胞标志物医嘱组类 医嘱组合 医嘱组合类 医嘱组套 医嘱组套类 医嘱组类 多重;多重型;多重标尺类型;多重精度类型 套餐 套餐医嘱 套餐医嘱组 套餐医嘱组类 实验室医嘱套餐 实验室医嘱套餐类 实验室医嘱组 实验室医嘱组合类 实验室医嘱组套 实验室医嘱组套类 实验室套餐医嘱组 实验室套餐医嘱组类 实验室检验项目医嘱组合类 实验室检验项目组合类 时刻;随机;随意;瞬间 检验医嘱组合类 检验项目医嘱组合类 检验项目组合类 流 流式细胞光度计;流式细胞测量术（Flow Cytometry，FC）;流式细胞计 组 组合 组合医嘱 组合类 组套 细胞标志物 自然杀伤细胞（NK细胞）细胞毒性.IL-2（白细胞介素 2、白介素 2） 刺激型（刺激法）组套（组合、医嘱组、套餐、套餐医嘱、医嘱套餐、组合申请、组合项目） 血;血液

LOINC Terminology Service (API) using HL7® FHIR® Get Info

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