LOINC
Version 2.70

98030-0Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC)Active

Term Description

NK cell cytotoxicity is used to evaluate patients with NK cell deficiency and genetic hemophagocytic lymphohistiocytosis and to measure NK cell cytotoxic function in postallogeneic hematopoietic cell transplantation and solid organ transplants.
Source: Regenstrief LOINC

Part Description

LP264987-1   Natural killer cell cytotoxicity
Natural killer cells are lymphocytes that identify and lyse tumor cells and cells infected with microbes. The ability of NK cells to recognize cells as foreign is dependent upon inhibitory and activating receptors on the target cells. The inhibitory receptors distinguish between normal and tumor or infected cells by the presence or absence of the major histocompatibility complex class I. The activating receptors are NKp46, NKp30, NKp44 and NKG2D. [PMID: 14685277] In addition to their cytolytic function in the innate immune system, NK cells also function to regulate reciprocal interaction with dendritic cells, macrophages, T cells and endothelial cells and thereby affect immune response. [PMID: 1842510] Patients that experience recurrent severe herpes infections, primary or secondary hemophagocytic lymphohistiocytosis, and suspected or known monogenic defects or patients who have received immune reconstitution post hematopoietic cell transplantation may lack the normal number or functionality of NK cells. The level of NK cell functionality is determined by various methods, including flow cytometry and chrominum-release assays. The chromium-release assay uses titrations of effector cells (that are assumed to be NK cells) that are incubated with the target cells. The level of chromium released by the target cells is then divided by the corrected level of chromium measured in the positive control to assess percent cytotoxicity. The flow cytometric methods measure cell-mediated immunity, particularly based on uptake of 7-amino-actinomycin D (7-AAD) or propidium iodide (PI) and Annexin V binding, to assess percent cytotoxicity of target cells by effector cells. [PMID: 11470149] Interleukin-2 (IL-2) has been found to increase the reactivity of NK cells against target cells [PMID: 23650441] and is used in some NK cell cytotoxicity assays. Source: Regenstrief LOINC

Panel Hierarchy
Details for each LOINC in Panel LHC-Forms

LOINC Name R/O/C Cardinality Example UCUM Units
98030-0 Natural killer cell cytotoxicity.IL-2 stimulated panel - Blood mononuclear cells by Flow cytometry (FC)
Indent33193-4 Viable cells/100 cells in Blood %
Indent90242-9 Natural killer cell cytotoxicity.IL-stimulated 0.9:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90243-7 Natural killer cell cytotoxicity.IL-stimulated 1.88:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90245-2 Natural killer cell cytotoxicity.IL-stimulated 3.75:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90249-4 Natural killer cell cytotoxicity.IL-stimulated 7.5:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90244-5 Natural killer cell cytotoxicity.IL-stimulated 15:1 effector to target cell ratio/Positive control in Blood mononuclear cells %
Indent90241-1 Natural killer cell cytotoxicity.IL-2 stimulated 30:1 effector to target cell ratio/Positive control in Blood mononuclear cells %

Fully-Specified Name

Component
Natural killer cell cytotoxicity.IL-2 stimulated panel
Property
-
Time
Pt
System
Bld MC
Scale
-
Method
Flow cytometry

Additional Names

Short Name
NK cyto IL2 Pnl Bld MC FC
Display Name
NK cytotoxicity.IL-2 stim panel FC (Bld MC)
Consumer Name Alpha
NK Cytotoxicity.IL-2 Stim panel, Blood

Basic Attributes

Class
PANEL.CELLMARK
Type
Laboratory
First Released
Version 2.70
Last Updated
Version 2.70
Order vs. Observation
Order
Panel Type
Panel

LOINC FHIR® API Example - CodeSystem Request Get Info

https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=98030-0