99075-4
Alpha-1-Microglobulin/Creatinine [Mass Ratio] in 24 hour Urine
Active
Part Descriptions
LP32035-5 Creatinine
Creatinine or creatine anhydride, is a breakdown product of creatine phosphate in muscle. The loss of water molecule from creatine results in the formation of creatinine. It is transferred to the kidneys by blood plasma, whereupon it is eliminated by glomular filtration and partial tubular excretion. Creatinine is usually produced at a fairly constant rate and measuring its serum level is a simple test. A rise in blood creatinine levels is observed only with marked damage to functioning nephrons; therefore this test is not suitable for detecting early kidney disease. Creatine and creatinine are metabolized in the kidneys, muscle, liver and pancreas.
Copyright Copyright ©2005-2009 Genome Alberta (Reference to original publication: Wishart DS, Knox C, Guo AC, et al. HMDB: a knowledgebase for the human metabolome. Nucleic Acids Res. 2009 37(Database issue):D603-610.)
Source: Human Metabolome Database,
Creatinine
LP40499-3 Alpha-1-Microglobulin
Alpha-1-microglobulin (also called protein HC or A1M) is a 31-kD, single-chain plasma glycoprotein that may be involved in regulation of the inflammatory process. The alpha-1-microglobulin/bikunin precursor gene (AMBP) codes for a precursor that splits into alpha-1-microglobulin, which belongs to the lipocalin superfamily, and bikunin. A1M is normally present as a free form and as a complex with IgA in the blood, spinal fluid, and urine. A1M inhibits neutrophil chemotaxis to endotoxin-activated serum. [OMIM: 176870] Abnormal plasma/serum levels can be seen in liver or kidney disorders, and also in clinical conditions such as HIV and mood disorders. Urinary A1M is used for the early detection and monitoring of kidney tubular disorders such as heavy metal intoxications, diabetic nephropathy, urinary outflow disorders or pyelonephritis). PMID: 15256311 Increased urinary excretion of α1-microglobulin in tubular proteinuria indicates reduced tubular reabsorption under normal glomerular filtration conditions. This form of proteinuria is typical for chronic interstitial nephropathy and for acute and chronic tubular damage caused by endogenous and exogenous tubular toxins. In renal failure, plasma levels of this microprotein increase from an early stage. The resultant protein hyperfiltration in the residual nephron causes increased renal excretion as re-absorption capacity is exceeded. α1-Microglobulin can be used as a marker to diagnose tubulo-interstitial nephropathy, for example, at an early stage, or rule it out with a high degree of certainty. Acute and chronic forms of tubular insufficiency (all forms of primary and secondary Fanconi syndrome), heavy metal intoxication, nephrotoxic side-effects of pharmaceuticals, and rejection reactions following kidney transplantation can also be excluded.
Source: Regenstrief LOINC,
PMID: 15256311
LOINC Names Get Info
- Fully-Specified Name
- Alpha-1-Microglobulin/Creatinine:
MRto: 24H: Urine: Qn: - Long Common Name
- Alpha-1-Microglobulin/Creatinine [Mass Ratio] in 24 hour Urine
- Short Name
- A1 Microglob/Creat 24h Ur
- Display Name
- Alpha-1-Microglobulin/Creatinine (24H U) [Mass ratio]
- Consumer Name Alpha Get Info
- Alpha-1-Microglobulin/Creatinine, Urine
Part Model Get Info
- Component
- Alpha-1-Microglobulin/Creatinine
LP284953-9
- Analyte
- Alpha-1-Microglobulin/Creatinine
LP284953-9
- Challenge
- NULL
- Adjustment
- NULL
- Count
- NULL
- Property
- MRto
LP6834-8
- Time
- 24H
LP6924-7
- Time Core
- 24H
LP6924-7
- Time Modifier
- NULL
- System
- Urine
LP7681-2
- System Core
- Urine
LP7681-2
- Super System
- NULL
- Scale
- Qn
LP7753-9
- Method
- NULL
Basic Attributes
- Class
- CHEM
- Type
- Laboratory
- First Released
- Version 2.72
- Last Updated
- Version 2.72 (ADD)
- Order vs. Observation
- Both
Member of these Groups Get Info
| LOINC Group | Group Name |
|---|---|
| LG51319-8 | Alpha-1-Microglobulin/Creatinine| |
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| cs-CZ | Czech (Czechia) | Alfa-1-mikroglobulin/kreatinin: |
| de-DE | German (Germany) | Alpha-1-Mikroglobulin/Creatinin: Synonyms: a1-Mikroglobulin |
| el-GR | Greek (Greece) | Α-1-μικροσφαιρίνη/Κρεατινίνη: Synonyms: 24H CHEM MRto Qn Α-1-μικροσφαιρίνη Κρεατινίνη Ούρα |
| es-ES | Spanish (Spain) | Alfa 1-microglobulina/Creatinina: Synonyms: Cuantitativo |
| et-EE | Estonian (Estonia) | Alfa-1-mikroglobuliin/kreatiniin: Synonyms: Kvantitatiivne Uriin |
| fr-CA | French (Canada) | Alpha-1-microglobuline/Créatinine: |
| fr-BE | French (Belgium) | Alpha-1-microglobuline/Créatinine: Synonyms: Rapport de masse |
| fr-FR | French (France) | Alpha-1-microglobuline/créatinine: |
| it-IT | Italian (Italy) | Alfa-1-Microglobulina/Creatinina: Synonyms: 24 Ore Chimica Rapporto di Massa |
| nl-NL | Dutch (Netherlands) | alfa-1-microglobuline/creatinine: Synonyms: 24U kreatinine |
| pl-PL | Polish (Poland) | Alfa-1-mikroglobulina/kreatynina: Synonyms: 24 godziny |
| ru-RU | Russian (Russian Federation) | Альфа-1-Микроглобулин/Креатинин: Synonyms: Количественный Масс отношение |
| tr-TR | Turkish (Turkey) | Alfa-1-Mikroglobulin/Kreatinin: |
| zh-CN | Chinese (China) | Alpha-1-微球蛋白/肌酐: Synonyms: 1天; |
Example Units
| Unit | Source |
|---|---|
| mg/g{creat} | Example UCUM Units |
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
LOINC Copyright
Copyright © Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://