Version 2.78

Term Description

Cross-reactive immunological material (CRIM) status in patients with Pompe disease is important when assessing whether immunosuppression is needed when initiating enzyme replacement therapy.
Source: Regenstrief LOINC

Part Description

LP429267-0   Acid alpha glucosidase cross-reactive immunologic material (CRIM)
Pompe disease (also known as glycogen storage disease type II and acid maltase deficiency) is an autosomal recessive disorder caused by a deficiency of the lysosomal enzyme acid α-glucosidase (GAA). Prompt diagnosis and initiation of enzyme replacement therapy with recombinant human GAA (rhGAA) are critical for reducing mortality and disability. A key predictor of clinical response to replacement therapy is a patient's CRIM (cross-reactive immunological material to GAA) status, which is based on the presence or absence of endogenous GAA. Patients who are CRIM-positive produce detectable GAA and are typically immunologically tolerant of rhGAA, whereas approximately 20% of patients who are CRIM-negative develop high levels of antibodies against exogenous rhGAA, which eventually reduces the efficacy of therapy PMID: 24044919. Source: Regenstrief LOINC

Fully-Specified Name

Component
Acid alpha glucosidase cross-reactive immunologic material (CRIM)
Property
PrThr
Time
Pt
System
Tissue
Scale
Ord
Method
IB

Additional Names

Short Name
AAG CRIM tiss Ql IB
Display Name
Acid alpha glucosidase cross-reactive immunologic material (CRIM) IB Ql (Tiss)
Consumer Name Alpha Get Info
Acid alpha glucosidase cross-reactive immunologic material (CRIM), Tissue

Example Answer List: LL360-9

Source: Regenstrief Institute
Answer Code Score Answer ID
PositiveCopyright http://snomed.info/sct ID:10828004 Positive (qualifier value) LA6576-8
NegativeCopyright http://snomed.info/sct ID:260385009 Negative (qualifier value) LA6577-6

Basic Attributes

Class
CHEM
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Material inmunológico de reacción cruzada con alfa glucosidasa ácida (CRIM):PrThr:Punto temporal:Tejido:Ord:Inmunoblot (IB)
fr-FR French (France) Alpha glucosidase acide Statut CRIM:Présence/Seuil:Ponctuel:Tissus:Qualitatif:Immunoblot
it-IT Italian (Italy) Alfa-glucosidasi acida materiale immunologico cross-reattivo (CRIM):PrThr:Pt:Tessuto:Ord:IB
Synonyms: Chimica Immunoblot (IB) Presenza o Soglia Punto nel tempo (episodio)
zh-CN Chinese (China) 酸性 alpha 葡萄糖苷酶交叉反应免疫物质:存在情况或阈值:时间点:组织:序数型:免疫印迹法
Synonyms: Alpha 葡萄糖苷酶;Alpha-1,4-葡糖苷酶;Alpha-1,4-葡萄糖苷酶;Alpha-葡糖苷酶;Alpha-葡萄糖苷酶;A-葡糖苷酶;A-葡萄糖苷酶;GAA;Pompe 氏病;Pompe 病;α-1,4-葡糖苷酶;α-1,4-葡萄糖苷酶;α葡糖苷酶;α-葡糖苷酶;α葡萄糖苷酶;α-葡萄糖苷酶;酸性麦牙糖酶;酸性麦芽糖酵素;酸性麦芽糖酶;麦牙糖酶;麦芽糖酵素;麦芽糖酶 α 依次型;分类顺序型;定性的;序数型（或称等级型）;性质上的;有序型;有序性分类应答;有序性分类结果;秩次型;等级型;筛查;顺序型 免疫 免疫印迹;西部印迹法;Immunoblot;immunoblotting;IB 免疫性的 免疫的 化学;化学检验项目;化学检验项目类;化学类;化学试验;非刺激耐受型化学检验项目;非刺激耐受型化学检验项目类;非刺激耐受型化学试验;非刺激耐受型化学试验类 原料;物质;素材;用料 反作用的 反应性 反应性的 反应的 存在情况;存在;存在与否;是否存在;阈值;界值;界限;阀值;临界值;存在情况（存在、存在与否、是否存在）或阈值（界值、界限、阀值、临界值） 时刻;随机;随意;瞬间 活性的 葡糖基蔗糖酶;葡萄糖苷酶;葡萄糖转化酶;麦牙糖酶;麦芽糖酶;麦芽糖酶-葡糖淀粉酶;麦芽糖酶-葡糖糖化酶 酸 酸性α葡萄糖苷酶交叉反应免疫物质;酸性α葡萄糖苷酶交叉反应性免疫物质;酸性α葡萄糖苷酶 CRIM;酸性α葡萄糖苷酶交叉免疫反应物质;酸性 alpha 葡萄糖苷酶交叉反应性免疫物质 阿尔法

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