Version 2.77

Part Descriptions

LP28510-3   Voltage-gated calcium channel
Voltage-dependent calcium channels (VDCC) are a group of voltage-gated ion channels found in excitable cells (e.g., muscle, glial cells, neurons, etc.) with a permeability to the ion Ca2+.At physiologic or resting membrane potential, VDCCs are normally closed. They are activated (i.e., opened) at depolarized membrane potentials and this is the source of the "voltage-dependent" epithet. Activation of particular VDCCs allows Ca2+ entry into the cell, which, depending on the cell type, results in muscular contraction, excitation of neurons, up-regulation of gene expression, or release of hormones or neurotransmitters. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

LP40151-0   Voltage-gated calcium channel Ab
Voltage gated calcium channel antibody test is used to diagnose Lambert-Eaton myasthenic syndrome, a paraneoplastic syndrome associated with small-cell lung carcinoma. Source: Quest Diagnostics Inc., Voltage-Gated Calcium Channel (VGCC) Ab

LP40151-0   Voltage-gated calcium channel Ab
Lambert-Eaton myasthenic syndrome (LEMS) is a rare autoimmune disorder that is characterised by muscle weakness of the limbs. It is the result of an autoimmune reaction, where antibodies are formed against presynaptic voltage-gated calcium channels in the neuromuscular junction (the connection between nerves and the muscle that they supply). Around 60% of those with LEMS have an underlying malignancy, most commonly small cell lung cancer; it is therefore regarded as a paraneoplastic syndrome (a condition that arises as a result of cancer elsewhere in the body).

In LEMS, antibodies against voltage-gated calcium channels (VGCC), particularly the P/Q-type VGCC, decrease the amount of calcium that can enter the nerve ending, hence less acetylcholine can be mobilized to the neuromuscular junction. Apart from skeletal muscle, the autonomic nervous system also requires acetylcholine neurotransmission; this explains the occurrence of autonomic symptoms in LEMS. P/Q voltage-gated calcium channels are also found in the cerebellum, explaining why some experience problems with coordination. The antibodies bind particularly to the part of the receptor known as the "domain III S5-S6 linker peptide". Antibodies may also bind other VGCCs. Some have antibodies that bind synaptotagmin, a protein involved in calcium-regulated vesicle transport, rather than against VGCC. Many people with LEMS, both with and without VGCC antibodies, have detectable antibodies against the M1 subtype of the acetylcholine receptor; it is thought that their presence participates in a lack of compensation for the slow calcium influx. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Fully-Specified Name

Component
Voltage-gated calcium channel Ab
Property
SCnc
Time
Pt
System
CSF
Scale
Qn
Method
IA

Additional Names

Short Name
VGCC Ab CSF IA-sCnc
Display Name
Voltage-gated calcium channel Ab IA (CSF) [Moles/Vol]
Consumer Name Alpha Get Info
Voltage-gated calcium channel antibody, Spinal fluid

Basic Attributes

Class
SERO
Type
Laboratory
First Released
Version 2.72
Last Updated
Version 2.72
Order vs. Observation
Both

Language Variants Get Info

Tag Language Translation
es-ES Spanish (Spain) Canales del Calcio dependientes del voltaje Anticuerpos:Concentración de sustancia:Punto temporal:Líquido Cefalorraquideo:Qn:IA
Synonyms: Cuantitativo
fr-CA French (Canada) Canaux calciques voltage-dépendants , Ac:Concentration de substance:Temps ponctuel:LCR:Quantitatif:IA
fr-BE French (Belgium) Canaux calciques voltage-dépendants Ac:Concentration de substance:Temps ponctuel:LCR:Quantitatif:IA
Synonyms: Anticorps
fr-FR French (France) Canaux calciques voltage dépendants anticorps:Moles/Volume:Ponctuel:Liquide céphalorachidien:Numérique:Immunoanalyse
it-IT Italian (Italy) Canale del calcio voltaggio-dipendente Ab:SCnc:Pt:LCS:Qn:IA
Synonyms: anticorpo Concentrazione di Sostanza Immunoassay Liquido cerebrospinale Punto nel tempo (episodio) Sierologia (anticorpi e la maggior parte degli ant
nl-NL Dutch (Netherlands) voltage-gated calciumkanaal As:mol/volume:moment:liquor cerebrospinalis:kwantitatief:immunoassay
Synonyms: antistof; antilichaam IA
ru-RU Russian (Russian Federation) Потенциал-зависимый кальциевый канал Ат:МолКонц:ТчкВрм:ЦСЖ:Колич:IA
Synonyms: Антитело Количественный Молярность;Молярная объёмная концентрация Точка во времени;Момент Цереброспинальная жидкость
tr-TR Turkish (Turkey) Voltaj kapılı kalsiyum channel Ab:SubKons:Zmlı:BOS:Kant:İA
Synonyms: Ak İmmünölçüm, immünoassay
zh-CN Chinese (China) 电压门控钙离子通道 抗体:物质的量浓度:时间点:脑脊液:定量型:免疫测定法
Synonyms: Ab;自身抗体 CA;Cal CSF CSF;脊髓液;Cerebral spinal fluid;脑脊髓液 克分子浓度;克分子浓度(单位体积);摩尔浓度;摩尔浓度(单位体积);物质的量浓度(单位体积) 免疫测定;免疫分析法;免疫检定法;免疫检定;免疫试验;酶免疫测定法;酶免疫测定;酶免疫分析法;酶免疫检定法;酶免疫检定;酶免疫试验 可用数量表示的;定量性;数值型;数量型;连续数值型标尺 时刻;随机;随意;瞬间 电压依赖性钙离子通道 Ab 电压依赖性钙离子通道;电压门控式钙离子通道;电压门控式钙通道;电压门控性钙离子通道;电压门控性钙通道;电压门控钙通道 电压依赖性钙离子通道抗体 电压门控式钙离子通道 Ab 电压门控式钙离子通道抗体 电压门控式钙通道 Ab 电压门控式钙通道抗体 电压门控性钙离子通道 Ab 电压门控性钙离子通道抗体 电压门控性钙通道 Ab 电压门控性钙通道抗体 电压门控钙离子通道 Ab 电压门控钙通道 Ab 电压门控钙通道抗体 脊液 脊髓液 脑脊液（Cerebral spinal fluid，CSF） 脑脊髓液 血清;血清学;血清学检验项目;血清学检验项目 (非微生物学);血清学检验项目（非微生物学）;血清学检验项目类;血清学检验项目类 (非微生物学);血清学类;血清学类检验项目;血清学类检验项目 (非微生物学);血清学类试验;血清学类试验 (非微生物学);血清学试验;血清学试验 (非微生物学);血清学试验（非微生物学）;血清学试验类 (非微生物学);血清类

Example Units

Unit Source
pmol/L Example UCUM Units

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=99411-1