LP101444-0
MAP2K2 gene
Active
Descriptions
The protein encoded by this MAP2K2 gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. The inhibition or degradation of this kinase is found to be involved in the pathogenesis of Yersinia and anthrax. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia
The MAP2K2 gene (mitogen-activated protein kinase kinase 2) [HGNC Gene ID:6842] is located on chromosome 19p13.3. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008] [NCBI Gene ID:5605] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- MAP2K2 gene
- Part Display Name
- MAP2K2 gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-08-03
- Construct for LOINC Short Name
- MAP2K2 gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | MAP2K2 基因 Synonyms: FLJ26075; |
| et-EE | Estonian (Estonia) | MAP2K2 geen |
| es-ES | Spanish (Spain) | Gen MAP2K2 |
| it-IT | Italian (Italy) | MAP2K2, gene Synonyms: Gene MAP2K2 |
| tr-TR | Turkish (Turkey) | MAP2K2 geni |
| ru-RU | Russian (Russian Federation) | MAP2K2 ген |
| nl-NL | Dutch (Netherlands) | MAP2K2-gen Synonyms: MAP2K2 gen |
| fr-FR | French (France) | MAP2K2 gène |
| pl-PL | Polish (Poland) | MAP2K2 gen Synonyms: Gen MAP2K2 |
| el-GR | Greek (Greece) | Γονίδιο MAP2K2 Synonyms: Γονίδιο MAP2K2 |
LOINC Copyright
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