LP101504-1
Fascin
Active
Description
Fascin is a actin cross-linking protein. It is a 54-58 kilodalton monomeric actin filament bundling protein originally isolated from sea urchin egg but also found in Drosophila and vertebrates, including humans. Fascin is spaced at 11 nanometre intervals along the filament. The bundles in cross section are seen to be hexagonally packed, and the longitudinal spacing is compatible with a model where fascin cross-links at alternating 4 and 5 actins. It is calcium insensitive and monomeric.
Fascin binds beta-catenin, and colocalizes with it at the leading edges and borders of epithelial and endothelial cells. The role of Fascin in regulating cytoskeletal structures for the maintenance of cell adhesion, coordinating motility and invasion through interactions with signalling pathways is an active area of research especially from the cancer biology perspective. Abnormal fascin expression or function has been implicated in breast cancer, colon cancer, esophageal squamous cell carcinoma, gallbladder cancer and prostate cancer.
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Fascin
- Part Display Name
- Fascin
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-08-27
- Construct for LOINC Short Name
- Fascin
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 肌成束蛋白 Synonyms: Fascin 蛋白; |
| et-EE | Estonian (Estonia) | Fastsiin |
| es-ES | Spanish (Spain) | Fascina |
| it-IT | Italian (Italy) | Fascina |
| tr-TR | Turkish (Turkey) | Faskin |
| ru-RU | Russian (Russian Federation) | Фасцин |
| nl-NL | Dutch (Netherlands) | fascine |
| fr-FR | French (France) | Fascine |
| pl-PL | Polish (Poland) | Fascyna |
| el-GR | Greek (Greece) | Φασκίνη Synonyms: Φασκίνη |
LOINC Copyright
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