LP111482-8
TOP2A gene
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Descriptions
DNA topoisomerase 2-alpha is an enzyme that in humans is encoded by the TOP2A gene.
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
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Source: Wikipedia,
Wikipedia
The TOP2A gene (topoisomerase (DNA) II alpha 170kDa) [HGNC Gene ID:11989] is located on chromosome 17q21-q22. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010] [NCBI Gene ID:7153] Source: National Center for Biotechnology Information (NCBI) Gene
Basic Part Properties
- Part Name
- TOP2A gene
- Part Display Name
- TOP2A gene
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2010-12-15
- Construct for LOINC Short Name
- TOP2A gene
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | TOP2A 基因 Synonyms: TOP2; |
| et-EE | Estonian (Estonia) | TOP2A geen |
| es-ES | Spanish (Spain) | Gen TOP2A |
| it-IT | Italian (Italy) | TOP2A, gene Synonyms: Gene TOP2A |
| tr-TR | Turkish (Turkey) | TOP2A geni |
| ru-RU | Russian (Russian Federation) | TOP2A ген |
| nl-NL | Dutch (Netherlands) | TOP2A-gen Synonyms: TOP2A gen |
| fr-FR | French (France) | TOP2A gène |
| pl-PL | Polish (Poland) | TOP2A gen Synonyms: Gen TOP2A |
| el-GR | Greek (Greece) | Γονίδιο TOP2A Synonyms: Γονίδιο TOP2A |
LOINC Copyright
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