Version 2.80

Descriptions

CCAAT/enhancer-binding protein alpha is a protein that in humans is encoded by the CEBPA gene. The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain promoters and enhancers. It can also form heterodimers with the related proteins CEBP-beta and CEBP-gamma. The encoded protein has been shown to bind to the promoter and modulate the expression of the gene encoding leptin, a protein that plays an important role in body weight homeostasis. Also, the encoded protein can interact with CDK2 and CDK4, thereby inhibiting these kinases and causing growth arrest in cultured cells.
Mutations of the CEBPA gene are a cause of familial AML, and positively correlate with better prognosis Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Wikipedia

The CEBPA gene (CCAAT/enhancer binding protein (C/EBP), alpha) [HGNC Gene ID:1833] is located on chromosome 19q13.1. This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013] [NCBI Gene ID:1050] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name
CEBPA gene
Part Display Name
CEBPA gene
Part Type
Component (Describes the core component or analyte measured)
Created On
2011-03-18
Construct for LOINC Short Name
CEBPA gene

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Language Variants Get Info

Tag Language Translation
et-EE Estonian (Estonia) CEBPA geen
it-IT Italian (Italy) CEBPA, gene
Synonyms: Gene CEBPA
zh-CN Chinese (China) CEBPA 基因
Synonyms: CCAAT/增强子结合蛋白α基因;CCAAT/增强子结合蛋白α;CCAAT促效結合蛋白α;CCAAT/enhancer binding protein alpha;C/EBPα
tr-TR Turkish (Turkey) CEBPA geni
ru-RU Russian (Russian Federation) CEBPA ген
es-ES Spanish (Spain) Gen CEBPA
nl-NL Dutch (Netherlands) CEBPA-gen
Synonyms: CEBPA gen
el-GR Greek (Greece) Γονίδιο CEBPA
Synonyms: Γονίδιο CEBPA