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Description

Heat shock proteins (HSP) are a class of functionally related proteins involved in the folding and unfolding of other proteins. Their expression is increased when cells are exposed to elevated temperatures or other stress. This increase in expression is transcriptionally regulated. The dramatic upregulation of the heat shock proteins is a key part of the heat shock response and is induced primarily by heat shock factor (HSF). HSPs are found in virtually all living organisms, from bacteria to humans.

Heat-shock proteins are named according to their molecular weight. For example, Hsp60, Hsp70 and Hsp90 (the most widely-studied HSPs) refer to families of heat shock proteins on the order of 60, 70 and 90 kilodaltons in size, respectively.

Hsp60 is involved in protein folding after its post-translational import to the mitochondrion/chloroplast.

HSP60 has been implicated in autoimmune disease as a result of its similarity to HSP65 of microorganisms. The development of antibodies against HSP60 has been hypothesized to trigger the ANCA response due to its corresponding homology to myeloperoxidase. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Name
Heat shock protein 60 Ab
Part Display Name
Heat shock protein 60 Ab
Part Type
Component (Describes the core component or analyte measured)
Created On
2011-09-29

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP135594-2

Language Variants Get Info

TagLanguageTranslation
fr-FRFrench (France)Protéine 60 du choc thermique anticorps
pl-PLPolish (Poland)Białko szoku cieplnego 60 Ab
Synonyms: Przeciwciała do białka szoku cieplnego 60 (HSP60)