LP135738-5
Lymphocyte proliferation.tetanus toxoid.maximum
Active
Descriptions
Proliferation of Candida albicans is used in the evaluation of patients with primary and secondary immunodeficiency diseases which affect T-lymphocytes. Recall antigens, such as Candida albicans and Tetanus toxoid, are capable of inducing anamnestic (recall) T cell response and stimulating lymphocyte proliferation. Used to assess T cell function in patients havingimmunosuppressive therapy and to evaluate patients with cellular or humoral immunodeficiency diseases, which include SCID (Severe Combined Immunodeficiency), CVID (Common Variable Immunodeficiency), and DiGeorge syndrome. Source: Regenstrief Institute
Lymphocyte proliferation to antigens and mitogens is performed by flow cytometry using a thymidine analogue called Edu®. Total lymphocytes are identified using a combination of the CD45 marker and FSC/SSC parameters, and total T cells with the CD3 marker from within the lymphocyte population. Three concentrations each for Candida (CA) and Tetanus (TT) (same for mitogens) are used and only the result at the concentration of antigen/mitogen that gives maximal response for that individual (since this can vary from person to person) is reported. The maximal % antigen-specific proliferating lymphocytes (CD45+) (numerator) relative to the total CD45+ lymphocyte population (denominator) is assessed. For T cells, the maximal response where the % CD3+ proliferating antigen-specific T cells is expressed relative to the total CD3+ T cell population is assessed.
The maximum as referred to above is the concentration of antigen or mitogen that gives the highest proliferating response.
Copyright Copyright © 1995-2009
Source: Mayo Medical Laboratories
Basic Part Properties
- Part Name
- Lymphocyte proliferation.tetanus toxoid.maximum
- Part Display Name
- Lymphocyte proliferation.tetanus toxoid.maximum
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2011-10-06
- Construct for LOINC Short Name
- LPT TT max
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| it-IT | Italian (Italy) | Linfociti, proliferazione.tetano toxoide.massimo Synonyms: Proliferazione linfocitaria.tetano toxoide.massimo |
| zh-CN | Chinese (China) | 淋巴细胞增殖.破伤风类毒素.最大值 Synonyms: PHA TT |
| tr-TR | Turkish (Turkey) | Lenfosit proliferasyonu.tetanus tokzoid.maksimum |
| ru-RU | Russian (Russian Federation) | Лимфоцит пролиферация.столбнячный токсоид.max Synonyms: Лимфоцит пролиферация.столбнячный анатоксин.максимум |
| es-ES | Spanish (Spain) | Proliferación de linfocitos. toxoide tetánico. máximo |
| nl-NL | Dutch (Netherlands) | lymfocytenproliferatie.tetanus toxoide.maximum |
| pl-PL | Polish (Poland) | Proliferacja limfocytu.toksoid tężcowy.maksymalna odpowiedź Synonyms: Proliferacja limfocytu po stymulacji toksoidem tężcowym, maksymalna odpowiedź |
| el-GR | Greek (Greece) | Πολλαπλασιασμός λεμφοκυττάρων.τοξοειδής τέτανος.μέγιστος Synonyms: Πολλαπλασιασμός λεμφοκυττάρων.τοξοειδής τέτανος.μέγιστος |
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