Version 2.77


Found on activated B- and T-cells
Associated with Reed-Sternberg cells and Large cell anaplastic lymphoma Source: Regenstrief Institute

CD30 is immunophenotypic marker useful for the detection of activated cells and anaplastic large cell lymphoma. Source: Regenstrief Institute

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.

This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See for details. Source: Wikipedia, CD30

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) CD30
Synonyms: BER-H2 AG;BER-H2抗原;KI-1 AG;KI-1抗原
fr-CA French (Canada) CD30
et-EE Estonian (Estonia) CD30
es-ES Spanish (Spain) CD30
it-IT Italian (Italy) CD30
tr-TR Turkish (Turkey) CD30
ru-RU Russian (Russian Federation) CD30
nl-NL Dutch (Netherlands) CD30
fr-BE French (Belgium) CD30
pl-PL Polish (Poland) CD30
Synonyms: CD30