LP14618-0
CD30
Active
Descriptions
Found on activated B- and T-cells
Associated with Reed-Sternberg cells and Large cell anaplastic lymphoma
Source: Regenstrief Institute
CD30 is immunophenotypic marker useful for the detection of activated cells and anaplastic large cell lymphoma. Source: Regenstrief Institute
CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker.
This receptor is expressed by activated, but not by resting, T and B cells. TRAF2 and TRAF5 can interact with this receptor, and mediate the signal transduction that leads to the activation of NF-kappaB. It is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
CD30 is associated with anaplastic large cell lymphoma. It is expressed in embryonal carcinoma but not in seminoma and is thus is a useful marker in distinguishing between these germ cell tumors.
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Source: Wikipedia, CD30
Basic Part Properties
- Part Display Name
- CD30
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- CD30
LOINC Terminology Service (API) using HL7® FHIR® Get Info
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- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP14618-0
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | CD30 Synonyms: BER-H2 AG; |
| fr-CA | French (Canada) | CD30 |
| et-EE | Estonian (Estonia) | CD30 |
| es-ES | Spanish (Spain) | CD30 |
| it-IT | Italian (Italy) | CD30 |
| tr-TR | Turkish (Turkey) | CD30 |
| ru-RU | Russian (Russian Federation) | CD30 |
| nl-NL | Dutch (Netherlands) | CD30 |
| fr-BE | French (Belgium) | CD30 |
| pl-PL | Polish (Poland) | CD30 Synonyms: CD30 |
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