LP150209-7
Promyelocytic leukemia protein distribution pattern
Active
Description
Acute promyelocytic leukemia (APL) involves the t(15;17)(PML;RARα )(q22;q12) translocation occurring between the promyelocytic leukemia (PML) gene and the retinoic acid receptor - alpha (RARα) gene, leading to expression of the PML- RARα fusion protein. This test detects the presence of this translocation by examining the subcellular distribution of PML by Immunofluorescence (IF). Normally, IF staining for PML using antibodies directed against the PML protein appears as a granular pattern of 5 to 30 discrete intranuclear particles. This is the case in normal cells. However, in acute promyelocytic leukemia, the PML- RARα fusion protein forms heterodimers with the wild type PML protein. This sequestration changes the cellular localization of PML such that IF staining becomes more diffuse, known as a microgranular pattern. Detecting APL is important because quickly beginning therapy with all trans retinoic acid is important for management Source: Regenstrief LOINC
Basic Part Properties
- Part Name
- Promyelocytic leukemia protein distribution pattern
- Part Display Name
- Promyelocytic leukemia protein distribution pattern
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-05-15
- Construct for LOINC Short Name
- PML protein pattern
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 早幼粒细胞白血病蛋白分布模式 Synonyms: 早幼粒细胞白血病蛋白; |
| es-ES | Spanish (Spain) | Patrón de distribución de proteínas en la leucemia promielocítica |
| it-IT | Italian (Italy) | Leucemia promielocitica, profilo distribuzione proteine |
| tr-TR | Turkish (Turkey) | Promiyelositik lösemi protein dağılım patterni |
| ru-RU | Russian (Russian Federation) | Промиелоцитарный лейкоз протеин распределение паттерн Synonyms: Промиелоцитарный лейкоз белок распределение паттерн |
| nl-NL | Dutch (Netherlands) | promyelocytenleukemie eiwitdistributie patroon |
| fr-FR | French (France) | Leucémie promyélocytaire distribution des protéines Profil |
| pl-PL | Polish (Poland) | Wzorzec rozkładu białek białaczki promielocytowej Synonyms: Profil rozkładu białek białaczki promielocytowej |
| el-GR | Greek (Greece) | Μοτίβο κατανομής πρωτεϊνών προμυελοκυτταρικής λευχαιμίας Synonyms: Μοτίβο κατανομής πρωτεϊνών προμυελοκυτταρικής λευχαιμίας |
LOINC Copyright
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