LP15076-0
Myeloblasts
Active
Description
The myeloblast is a unipotent stem cell, which will differentiate into one of the effectors of the Granulocyte series.
These cells descend from the primitive reticulum cells, which are found in the stroma of the marrow. There is also an intermediate phase between the myeloblast and these primitive reticulum cell, namely the hemocytoblast. At this time several developing blood cell lines are available, like erythropoiesis and thrombopoiesis. The granulopoiesis is regulated by humoral agents, like Colony Stimulating Factor and Interleukin 3.
Most common problem with malfunctioning myeloblasts is the acute myeloblastic leukemia. The main clinical features are caused by failure of the hemopoiesis with anemia, hemorrhage and infection as result. There is a progressive accumulation of leukemic cells, because some blast progenitor cells renew themselves and will have a limited differentiated division. Key mediators are the cell-density and Colony Stimulating Factor(CSF). A few acute myeloblastic leukemia can be initiated by earlier hematologic disorder, like pancytopenia, hypoplasia of the bone marrow.
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Source: Wikipedia, Myeloblasts (Wikipedia)
Basic Part Properties
- Part Display Name
- Myeloblasts
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Myeloblasts
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 原始粒细胞 Synonyms: 原粒细胞; |
| fr-CA | French (Canada) | Myéloblastes |
| et-EE | Estonian (Estonia) | Müeloblastid |
| es-ES | Spanish (Spain) | Mieloblastos |
| it-IT | Italian (Italy) | Mieloblasti |
| tr-TR | Turkish (Turkey) | Miyeloblastlar |
| ru-RU | Russian (Russian Federation) | Миелобласты |
| nl-NL | Dutch (Netherlands) | myeloblasten |
| fr-BE | French (Belgium) | Myéloblastes |
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