LP15250-1
Y little t super little b
Active
Description
The two antigens of the Yt system, Yt^a and Yt^b, are both expressed at birth, however in a slightly lower expression level than seen on adult cells. They were shown to be resistant to trypsin treatment, but sensitive to other protein cleaving enzymes. Antibodies to these antigens were implicated in cases of delayed transfusion reactions but were not reported to have caused hemolytic disease of the newborn. No examples of Yt(a-b-) individuals have been found despite numerous studies. From population studies, Yt^b appeared to be lacking, or of very low incidence, from Orientals, Amer-Indians and southern Africans; Yta was found lacking in approximately one per thousand individuals of European origin.
This system remained unexciting until it was found that both of these antigens were weak or absent from paroxysmal nocturnal hemoglobinuria (PNH) III red blood cells. With a rush of activity in the early 1990's, it was found that the Yt blood group system antigens represented amino acid substitutions on the GPI-linked glycoprotein, acetylcholinesterase (AchE). This protein probably exists as a dimer (pair) in the red cell membrane. Yta and Ytb are equated to substitutions of a hisitidine and asparagine, respectively, at amino acid position 322 on the GPI-linked glycoprotein. AChE has been assigned a chromosome location at 7q22.
Source: Serum, Cells and Rare Fluid Exchange, Yt^a
Basic Part Properties
- Part Name
- Y little t super little b
- Part Display Name
- Yt^b
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Yt sup(b)
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | Yt^b Synonyms: Y little t super little b; |
| fr-CA | French (Canada) | Y petit t exposant petit b |
| et-EE | Estonian (Estonia) | Yt^b |
| es-ES | Spanish (Spain) | Ytb |
| it-IT | Italian (Italy) | Y t minuscola apice b Synonyms: Yt^b |
| tr-TR | Turkish (Turkey) | Y küçük t süper küçük b |
| ru-RU | Russian (Russian Federation) | Y малое t супер малое b |
| nl-NL | Dutch (Netherlands) | Y kleine t super kleine b |
| fr-BE | French (Belgium) | Y petit t exposant petit b |
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