Version 2.80

Descriptions

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin.

It is sometimes produced in non-islet cell tumours, causing hypoglycemia (Doege-Potter syndrome). Loss of imprinting of IGF2 is a common feature in tumours seen in Beckwith-Wiedeman syndrome. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia , Wikipedia

Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The major role of IGF-2 is as a growth promoting hormone during gestation. IGF-2 exerts its effects by binding to the IGF-1 receptor. IGF2 may also bind to the IGF-2 receptor (also called the cation-independent mannose 6-phosphate receptor), which acts to prevent IGF2 responses. IGF-2 has also been shown to interact with IGFBP3 and transferrin.

IGF-2 is sometimes produced in excess in islet cell tumors, causing hypoglycemia. Doege-Potter syndrome is a paraneoplastic syndrome in which hypoglycemia is associated with the presence of one or more non-islet fibrous tumors in the pleural cavity. Loss of imprinting of IGF2 is a common feature in tumors seen in Beckwith-Wiedemann syndrome. As IGF2 promotes development of fetal pancreatic beta cells, it is believed to be related to some forms of diabetes mellitus. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia

Basic Part Properties

Part Name
Insulin-like growth factor-II
Part Display Name
Insulin-like growth factor-II
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
IGF-II

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Language Variants Get Info

Tag Language Translation
zh-CN Chinese (China) 胰岛素样生长因子-II
Synonyms: IGF-II;胰岛素样生长因子 II;胰岛素样生长因子 II（Insulin-like Growth Factor II，IGF-II）;胰岛素样生长因子Ⅱ;胰岛素样生长因子-Ⅱ
es-ES Spanish (Spain) Factor de crecimiento insulínico tipo II
it-IT Italian (Italy) Fattore di crescita insulino-simile II
et-EE Estonian (Estonia) Insuliinisarnane kasvufaktor 2
tr-TR Turkish (Turkey) İnsülin benzeri büyüme faktörü-II
ru-RU Russian (Russian Federation) Инсулиноподобный ростовой фактор-II
fr-BE French (Belgium) Facteur de croissance insulinomimétique-II
fr-CA French (Canada) Facteur de croissance insulinomimétique-II
nl-NL Dutch (Netherlands) insulin-like growth factor-II
el-GR Greek (Greece) Ινσουλινόμορφος αυξητικός παράγοντας IΙ
Synonyms: Ινσουλινόμορφος αυξητικός παράγοντας IΙ