LP157213-2
Centromere protein A Ab
Active
Description
Centromere protein A, also known as Histone H3-like centromeric protein A (CENP-A), replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. It is required for recruitment and assembly of kinetochore proteins, progression of mitosis and segregation of chromosomes. [UniProt: P49450] Anti-CENP-A antibodies are a marker of systemic sclerosis (SSc), a multisystem autoimmune connective tissue disorder that is characterized by vascular abnormalities, excessive collagen synthesis, and autoantibodies to nuclear and nucleolar proteins. Approximately 20-40% of patients with SSc are positive for anti-CENP-A or-B antibodies, and these patients are at higher risk of developing pulmonary arterial hypertension, but a lower risk of early interstitial lung disease, at least early in the disease course. PMID: 26455561 Source: Regenstrief LOINC , PMID: 26455561
Basic Part Properties
- Part Name
- Centromere protein A Ab
- Part Display Name
- Centromere protein A Ab
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-08-21
- Construct for LOINC Short Name
- Centromere A Ab
LOINC Terminology Service (API) using HL7® FHIR® Get Info
Requests to this service require a free LOINC username and password. Below is a sample of the possible capabilities. See the LOINC Terminology Service documentation for more information.
- CodeSystem lookup
- https:
//fhir.loinc.org/CodeSystem/$lookup?system=http: //loinc.org&code=LP157213-2
Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| pl-PL | Polish (Poland) | Białko centromerowe A Ab Synonyms: Przeciwciała do białka centromerowego A |
LOINC Copyright
Copyright © 2025 Regenstrief Institute, Inc. All Rights Reserved. To the extent included herein, the LOINC table and LOINC codes are copyright © Regenstrief Institute, Inc. and the Logical Observation Identifiers Names and Codes (LOINC) Committee. See https://