LP157266-0
Platelet-derived growth factor receptor
Active
Descriptions
Platelet-derived growth factor receptors (PDGFRs) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family. PDGF subunits -A and -B are important factors regulating cell proliferation, cellular differentiation, cell growth, development and many diseases including cancer. There are two forms of the PDGFR-- alpha and beta -- each encoded by a different gene. Depending on which growth factor is bound, PDGFR homo- or heterodimerizes. Like many other growth factors that have been linked to disease, PDGF and its receptors have provided a market for receptor antagonists to treat disease. Such antagonists include (but are not limited to) specific antibodies that target the molecule of interest, which act only in a neutralizing manner. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, PDFGR (Wikipedia)
Antibodies to the platelet derived growth factor receptor (PDGFR) are a marker of systemic sclerosis. Anti-PDGFR antibodies activate the PDGFR and stimulate production of reactive oxygen species (ROS) and collagen. In contrast to normal PDGF receptor activation, which is typically short-lived, PDGFR antibodies cause persistent activation and therefore prolonged stimulation of ROS production and collagen overproduction, which leads to fibrosis. PMID: 18083509 Source: Regenstrief LOINC, PMID: 18083509
Basic Part Properties
- Part Display Name
- Platelet-derived growth factor receptor
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2012-09-07
- Construct for LOINC Short Name
- PDGFR
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- CodeSystem lookup
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 血小板衍生生长因子受体 Synonyms: Platelet-derived growth factor receptor; |
| es-ES | Spanish (Spain) | Receptor del factor de crecimiento derivado de plaquetas |
| it-IT | Italian (Italy) | Fattore di crescita derivato dalle piastrine, recettore Synonyms: Recettore del fattore di crescita derivato dalle piastrine |
| tr-TR | Turkish (Turkey) | Trombositten-türeyen büyüme faktörü reseptörü |
| ru-RU | Russian (Russian Federation) | Пластинок роста фактор рецептор Synonyms: Рецептор к фактору роста, продуцируемому кровяными пластинками |
| nl-NL | Dutch (Netherlands) | Trombocyten-afgeleide groeifactorreceptor |
| pl-PL | Polish (Poland) | Receptor płytkopochodnego czynnika wzrostu |
LOINC Copyright
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