LP157531-7

CYP2E1 gene

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Description

The CYP2E1 gene (cytochrome P450, family 2, subfamily E, polypeptide 1) [HGNC Gene ID:2631] is located on chromosome 10q26.3. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is induced by ethanol, the diabetic state, and starvation. The enzyme metabolizes both endogenous substrates, such as ethanol, acetone, and acetal, as well as exogenous substrates including benzene, carbon tetrachloride, ethylene glycol, and nitrosamines which are premutagens found in cigarette smoke. Due to its many substrates, this enzyme may be involved in such varied processes as gluconeogenesis, hepatic cirrhosis, diabetes, and cancer. [provided by RefSeq, Jul 2008] [NCBI Gene ID:1571] Source: National Center for Biotechnology Information (NCBI) Gene

Basic Part Properties

Part Name

CYP2E1 gene

Part Display Name

CYP2E1 gene

Part Type

Component (Describes the core component or analyte measured)

Created On

2012-10-15

Construct for LOINC Short Name

CYP2E1

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