LP15800-3
Phosphoenolpyruvate carboxykinase
Active
Description
Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme in the lyase family used in the metabolic pathway of gluconeogenesis. It converts oxaloacetate into phosphoenolpyruvate and carbon dioxide. It is found in two forms, cytosolic and mitochondrial.
This is a rate-controlling step of gluconeogenesis, the process by which cells synthesize glucose from metabolic precursors. The blood glucose level is maintained within well-defined limits in part due to precise regulation of PEPCK gene expression. To emphasize the importance of PEPCK in glucose homeostasis, over expression of this enzyme in mice results in symptoms of type II diabetes mellitus, by far the most common form of diabetes in humans. Due to the importance of blood glucose homeostasis, a number of hormones regulate a set of genes (including PEPCK) in the liver that modulate the rate of glucose synthesis.
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Phosphoenolpyruvate carboxykinase
- Part Display Name
- Phosphoenolpyruvate carboxykinase
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- PEPCK
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 磷酸烯醇式丙酮酸羧激酶 Synonyms: GTP; |
| fr-CA | French (Canada) | Phosphoénolpyruvate carboxykinase |
| et-EE | Estonian (Estonia) | Fosfoenoolpüruvaadi karboksükinaas |
| es-ES | Spanish (Spain) | Fosfoenolpiruvato carboxiquinasa |
| it-IT | Italian (Italy) | Fosfoenolpiruvato carbossichinasi |
| tr-TR | Turkish (Turkey) | Fosfoenolpiruvat karboksikinaz |
| ru-RU | Russian (Russian Federation) | Фосфоенолпируват карбоксикиназа Synonyms: Фосфоенолпируват-карбоксикиназа |
| nl-NL | Dutch (Netherlands) | fosfo-enolpyruvaatcarboxykinase |
| fr-BE | French (Belgium) | Phosphoénolpyruvate carboxykinase |
| fr-FR | French (France) | Phosphoénolpyruvate carboxykinase |
| el-GR | Greek (Greece) | Φωσφοενολοπυροσταφυλική καρβοξυκινάση Synonyms: Φωσφοενολοπυροσταφυλική καρβοξυκινάση |
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