LP15852-4
Retinoate
Active
Description
Retinoic acid is the oxidized form of Vitamin A, with only partial vitamin A function. It functions in determining position along embryonic anterior/posterior axis in chordates. It acts through Hox genes, which ultimately control anterior/posterior patterning in early developmental stages. Retinoic acid acts by binding to heterodimers of the retinoic acid receptor (RAR) and the retinoid X receptor (RXR), which then bind to retinoic acid response elements (RAREs) in the regulatory regions of direct targets (including Hox genes), thereby activating gene transcription. Retinoic acid receptors mediate transcription of different sets of genes of cell differentiation, thus it also depends on the target cells. One of the target genes is the gene of the retinoic acid receptor itself, which occurs during positive regulation. Control of retinoic acid levels is maintained by a suite of proteins.
Retinoic acid can be produced by oxidation in the body from either retinal or retinol, but, once produced, cannot be reduced again.
Retinoic acid is responsible for all of the activity of vitamin A, save visual pigment effects, which require retinal (retinaldehyde), and for effects that require retinol in both the male and female reproductive tracts. Vitamin A-deprived retinoic acid-supplemented male rats exhibit hypogonadism and infertility; similar treatment of female rats causes infertility due to fetal resorption.
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Source: Wikipedia,
Wikipedia
Basic Part Properties
- Part Name
- Retinoate
- Part Display Name
- Retinoate
- Part Type
- Component (Describes the core component or analyte measured)
- Created On
- 2000-05-04
- Construct for LOINC Short Name
- Retinoate
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Language Variants Get Info
| Tag | Language | Translation |
|---|---|---|
| zh-CN | Chinese (China) | 视黄酸 Synonyms: 维生素 A 酸; |
| et-EE | Estonian (Estonia) | Retinoaat |
| es-ES | Spanish (Spain) | Retinoato |
| it-IT | Italian (Italy) | Retinoato |
| tr-TR | Turkish (Turkey) | Retinoat |
| ru-RU | Russian (Russian Federation) | Ретионат |
| nl-NL | Dutch (Netherlands) | retinoaat |
| fr-FR | French (France) | Rétinoate |
| el-GR | Greek (Greece) | Ρετινοϊκό οξύ Synonyms: Ρετινοϊκό οξύ |
LOINC Copyright
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