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Description

The enzyme UDP-glucose 4-epimerase (EC 5.1.3.2), also known as UDP-galactose 4-epimerase or GALE, is a homodimeric epimerase found in bacterial, plant, and mammalian cells. This enzyme performs the final step in the Leloir pathway of galactose metabolism, catalyzing the reversible conversion of UDP-galactose to UDP-glucose. GALE tightly binds nicotinamide adenine dinucleotide (NAD+), a co-factor required for catalytic activity.

Additionally, human and some bacterial GALE isoforms reversibly catalyze the formation of UDP-N-acetylgalactosamine (UDP-GalNAc) from UDP-N-acetylglucosamine (UDP-GlcNAc) in the presence of NAD+, an initial step in glycoprotein or glycolipid synthesis.

Human GALE deficiency or dysfunction results in Type III galactosemia, which may exist in a mild (peripheral) or more severe (generalized) form. Copyright Text is available under the Creative Commons Attribution/Share-Alike License. See http://creativecommons.org/licenses/by-sa/3.0/ for details. Source: Wikipedia, Wikipedia

Basic Part Properties

Part Name
Uridine diphosphate glucose-4-Epimerase
Part Display Name
Uridine diphosphate glucose-4-Epimerase
Part Type
Component (Describes the core component or analyte measured)
Created On
2000-05-04
Construct for LOINC Short Name
UDPG4Epimerase

LOINC Terminology Service (API) using HL7® FHIR® Get Info

CodeSystem lookup
https://fhir.loinc.org/CodeSystem/$lookup?system=http://loinc.org&code=LP15936-5

Language Variants Get Info

TagLanguageTranslation
zh-CNChinese (China)尿苷二磷酸葡糖-4-表异构酶
Synonyms: UDPG4Epimerase;UDP-半乳糖-4-差向异构酶;UDP-半乳糖-4-差向酶;UDP-半乳糖-4-表异构酶;UDP-葡糖-4-差向异构酶;UDP-葡糖-4-差向酶;UDP-葡糖-4-表异构酶;二磷酸尿苷半乳糖-4-差向异构酶;二磷酸尿苷半乳糖-4-差向酶;二磷酸尿苷半乳糖-4-表异构酶;二磷酸尿苷葡糖-4-差向异构酶;二磷酸尿苷葡糖-4-差向酶;二磷酸尿苷葡糖-4-表异构酶;尿苷二磷酸半乳糖-4-差向异构酶;尿苷二磷酸半乳糖-4-差向酶;尿苷二磷酸半乳糖-4-表异构酶;尿苷二磷酸葡糖-4-差向
fr-CAFrench (Canada)Uridine diphosphate glucose-4-épimérase
et-EEEstonian (Estonia)Uridiindifosfaadi glükoos-4-epimeraas
es-ESSpanish (Spain)Uridin-difostato-glucosa-4-Epimerasa
it-ITItalian (Italy)Uridina difosfato glucosio-4-Epimerasi
tr-TRTurkish (Turkey)Üridin difosfat glukoz-4-Epimeraz
ru-RURussian (Russian Federation)Уридин дифосфат глюкозо-4-Эпимераза
nl-NLDutch (Netherlands)uridinedifosfaatglucose-4-epimerase
fr-BEFrench (Belgium)Uridine diphosphate glucose-4-épimérase
fr-FRFrench (France)Uridine diphosphate glucose-4-épimérase
pl-PLPolish (Poland)4-Epimeraza urydylodifosfoglukozy
Synonyms: 4-Epimeraza urydylodifosfoglukozy
el-GRGreek (Greece)Ουριδινο-διφωσφο-γαλακτόζη-4-επιμεράση
Synonyms: Ουριδινο-διφωσφο-γαλακτόζη-4-επιμεράση